tailieunhanh - In vitro antibacterial studies of ciprofloxacin imines and their complexes with Cu(II),Ni(II),Co(II), and Zn(II)

Some new transition metal complexes of ciprofloxacin-imines derived from ciprofloxacin and p-substituted anilines were synthesized and characterized on the basis of physical properties, conductance measurements, elemental analysis, UV/Vis., infrared and nuclear magnetic resonance spectroscopy. | Turk J Biol 31 (2007) 67-72 © TÜB‹TAK In Vitro Antibacterial Studies of Ciprofloxacin-imines and Their Complexes with Cu(II),Ni(II),Co(II), and Zn(II) 1 2 3 3 Muhammad IMRAN , Javed IQBAL , Shahid IQBAL , Nazia IJAZ 1 Undergraduate Block, University of the Punjab, Lahore - PAKISTAN 2 Institute of Chemistry, Punjab University, Lahore - PAKISTAN 3 Department of Chemistry, University of Sargodha, Sargodha- 40100 - PAKISTAN Received: Abstract: Some new transition metal complexes of ciprofloxacin-imines derived from ciprofloxacin and p-substituted anilines were synthesized and characterized on the basis of physical properties, conductance measurements, elemental analysis, UV/Vis., infrared and nuclear magnetic resonance spectroscopy. These ligands as well as their metal complexes were also evaluated for their antibacterial activity against several bacterial strains, such as Staphylococcus aureus, Bacillus subtilus, Salmonella typhae, and E. coli. It was found that metal complexes are more antibacterial as compared to uncomplexed ligands. The present study was carried out in search of a target antibiotic instead of a broad spectrum one. Key Words: Ciprofloxacin imines, coordination compounds, antibacterial activity Introduction Compounds containing an azomethine group are known as imines (Schiff bases). The chelating abilities, and analytical and biological applications of these compounds have attracted remarkable attention (1-3). Antibiotics such as Streptomycin, aspergillic acid, usnic acid, and tetracycline are known to have chelating properties. Presumably some antibiotics are delicately balanced so as to be able to compete successfully with the metal-binding agents of bacteria while not disturbing the metal processing by the host. There is evidence that at least some bacteria have developed resistance to antibiotics through the development of altered enzyme systems that can compete successfully with antibiotics. The action of the antibiotic .