tailieunhanh - Characterization and biological activity of Achillea teretifolia willd. and A. nobilis L. subsp. neilreichii (Kerner) Formanek essential oils

The aerial parts of the endemic Achillea teretifolia Willd. and A. nobilis L. subsp. neilreichii (Kerner) Formanek collected from Beyşehir were investigated for their essential oil compositions and several biological activities. The essential oils were analyzed both by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). | Turk J Biol 33 (2009) 129-136 © TÜBİTAK doi: Characterization and Biological Activity of Achillea teretifolia Willd. and A. nobilis L. subsp. neilreichii (Kerner) Formanek Essential Oils Fatih DEMİRCİ1, Betül DEMİRCİ1, İlhan GÜRBÜZ2, Erdem YEŞİLADA3, K. Hüsnü Can BAŞER1 1 Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir - TURKEY 2 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, 06330 Ankara - TURKEY 3 Department of Pharmacognosy, Faculty of Pharmacy, Yeditepe University, 34755 İstanbul - TURKEY Received: Abstract: The aerial parts of the endemic Achillea teretifolia Willd. and A. nobilis L. subsp. neilreichii (Kerner) Formanek collected from Beyşehir were investigated for their essential oil compositions and several biological activities. The essential oils were analyzed both by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The main components were identified as 1,8-cineole (34%), camphor (11%), terpinen-4-ol (8%), and α-thujone (5%) for A. teretifolia essential oil, while fragranyl acetate (32%), fragranol (24%), and β-eudesmol (8%) for A. nobilis subsp. neilreichii essential oil, respectively. The essential oils were also evaluated for their in vitro antimicrobial activity and their ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals using microdilution techniques as an index for the evaluation of antioxidant activity. Both essential oils were found to be effective against the tested human pathogenic microorganisms (MIC to >2 mg/ml) and DPPH (IC50 > mg/ml) assay as compared to the references. Key Words: Asteraceae; Achillea; essential oil; GC and GC-MS; antimicrobial activity; antioxidant activity Achillea teretifolia Willd. ve A. nobilis L. subsp. neilreichii (Kerner) Formanek Uçucu Yağlarının Kimyasal Bileşimi ve Biyolojik Aktivitesi Özet: Bu çalışmada, Beyşehir’den toplanan endemik bir tür olan Achillea teretifolia .

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• Essential oil
• Antimicrobial activity
• Antioxidant activity
• Gas chromatography mass spectrometry
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