tailieunhanh - In vitro antimicrobial and antioxidant activities of methanol and hexane extract of Astragalus species growing in the Eastern Anatolia region of Turkey

This study was conducted to evaluate the antimicrobial and antioxidant activities of the hexane and methanol extracts of the aboveground parts and roots of some Astragalus species grown in the vicinity of Erzurum, located in the eastern Anatolia, Turkey. | Turk J Biol 33 (2009) 65-71 © TÜBİTAK doi: In vitro Antimicrobial and Antioxidant Activities of Methanol and Hexane Extract of Astragalus Species Growing in the Eastern Anatolia Region of Turkey Ahmet ADIGÜZEL1, Münevver SÖKMEN2, Hakan ÖZKAN3, Güleray AĞAR4, Medine GÜLLÜCE4, Fikrettin ŞAHİN5 1 Health Services Vocational Training School, Atatürk University, 25070, Erzurum - TURKEY 2 Department of Chemistry, Faculty of Art and Science, Karadeniz Technical University, Trabzon - TURKEY 3 Turkish Ministry of Health, Erzurum Regional Hygiene Institute, 25100, Erzurum - TURKEY 4 Department of Biology, Faculty of Art and Science, Atatürk University, 25240, Erzurum - TURKEY 5 Department of Genetic and Bioengineering, Faculty of Engineering and Architecture, Yeditepe University, 34755, Istanbul - TURKEY Received: Abstract: This study was conducted to evaluate the antimicrobial and antioxidant activities of the hexane and methanol extracts of the aboveground parts and roots of some Astragalus species grown in the vicinity of Erzurum, located in the eastern Anatolia, Turkey. The methanol extract, which was obtained from the aboveground parts of Astragalus species, exhibited mild free radical scavenging activity providing 50% inhibition at the concentrations between and μg/ml. The hexane/dichloromethane extracts of the aboveground parts of Astragalus species did not show any free radical scavenging activity. However, the linoleic acid oxidation inhibition ability of the non-polar extracts seems to be higher than that of the polar methanolic extracts. The methanol root extracts were mild antioxidants but the non-polar root extracts of A. microcephalus Willd., A. macrocephalus Willd., A. erinaceus Fisch. & Mey. ex Fischer, A. psoraloides Lam., and A. argyroides Becker ex Stapf. were extremely active in DPPH test. IC50 values were μg/ml, μg/ml, μg/ml μg/ml, and μg/ml, respectively. In the case of .