tailieunhanh - The relationship between SNP rs895819 (A>G) on miRNA-27a and the breast cancer in the Vietnamese population

Breast cancer (BC), the most common type of cancer among women worldwide, is a polygenetic disease which is caused by the interaction of several genes. Understanding the genetic factors for early diagnosis of BC is crucial to ensure the survival of BC patients. MicroRNA 27a (miR-27a), an oncogenic miRNA, has been predicted to target on the tumor suppressor ZBTB10 that can regulate many processes of cell. | TAÏP CHÍ PHAÙT TRIEÅN KH&CN, TAÄP 19, SOÁ T5- 2016 The relationship between SNP rs895819 (A>G) on miRNA-27a and the breast cancer in the Vietnamese population Nguyen Ba Hung Phong Tran Thi Hong Minh Nguyen Thi Ngoc Thanh Nguyen Thi Hue University of Science, VNU-HCMC (Received on 17th November 2015, accepted on 2nd December 2016) ABSTRACT Breast cancer (BC), the most common type of samples were genotyped using an optimal HRM cancer among women worldwide, is a protocol then statistical analysis was applied to polygenetic disease which is caused by the examine the relationship of the SNP. In the case interaction of several genes. Understanding the group, the risk G allele accounted for 36 % while genetic factors for early diagnosis of BC is in the control group it took up 32 %. Statistic crucial to ensure the survival of BC patients. result revealed that rs895819 (A>G) had no MicroRNA 27a (miR-27a), an oncogenic miRNA, significant relationship with the breast cancer has been predicted to target on the tumor (OR=; P=) in given case-control suppressor ZBTB10 that can regulate many samples. Although the SNP is significantly processes of cell. Single nucleotide ralated with BC in German or Chinese polymorphism (SNP) rs895819 alters the populations, it is not a potential marker for structure and function of miR-27a, which has diagnosis in the Vietnamese population. Further been anticipated to reduce the risk of BC in studies investigating relationship between different populations such as German and rs895819 (A>G) and breast cancer in the Chinese. This study aimes to investigate the Vietnamese population is not recommended. In relationship between the existence of SNP future, other SNPs should be investigated with rs895819 (A>G) and the risk of BC using the the aim of identification efficient biomarker for optimized high resolution melting (HRM) early diagnosis of BC in Vietnamese. method. 106 BC samples and 117 healthy Key words: Breast cancer, .