tailieunhanh - Saponin phytosome: A solution to enhance bioavailability of saponin

Saponin is a group of compounds occurring naturally in plants and animals. These compounds may own important biological effects. One of the factors reducing their pharmacological effect in vivo of these compounds is poor bioavailability. | JOURNAL OF MILITARY PHARMACO-MEDICINE N07-2016 SAPONIN PHYTOSOME: A SOLUTION TO ENHANCE BIOAVAILABILITY OF SAPONIN (A REVIEW) Nguyen Van Long*; Dang Truong Giang*; Vu Tuan Anh* Nguyen Thi Lan Huong*; Nguyen Thi Thu Hoai* SUMMARY Saponin is a group of compounds occurring naturally in plants and animals. These compounds may own important biological effects. However, one of the factors reducing their pharmacological effect in vivo of these compounds is poor bioavailability. There are many factors affecting the bioavailability of saponins including solubility, stability and permeability. Phytosomal technology is able to improve the bioavailability of saponins in vivo by increasing solubility, stability and permeability of these compounds. This study aims to review the advances of this modern technology to enhance bioavailability of saponin. * Key words: Saponin; Bioavailability; Phosphatidylcholine; Phytosomal technology. INTRODUCTION Saponin is a class of glycosides found abundantly in various plant species. In terms of chemical structure, saponin can be divided into two groups: triterpenoid saponins and steroidal saponins. In general, saponins have many pharmacological effects as expectorant, anti-inflammatory, antihypertensive, immuno-modulatory, hypoglycemia, antifungal, antiparasitic effects, etc ) [1]. However, the major challenge in developing saponins as clinically useful drugs is their poor bioavailability. The poor bioavailability of saponins was caused by the physicochemical properties of its (. solubility, stability) and the ability of saponins to permeate a biological membrane [7]. There were few reports about the pharmaceutical formulation study to enhance the oral bioavailability of saponins such as nanoparticles, liposome, phytosome . This report aims to review some factors affect the bioavailability of saponins and phytosomal technology bioavailability of saponins. to enhance BIOAVAILABILITY OF SAPONINS Some recent studies showed that .