tailieunhanh - Relation between plasma homocysteine, folate, vitamin b12 levels with blood pressure, residual renal function, anemia, dialysis duration and serum albumin in maintenance hemodialysis patients

Objectives: To analyze relation between levels of plasma homocysteine (Hcy), folate, vitamin B12 with blood pressure (BP), residual renal function (RRF), anemia, dialysis duration and serum albumin in hemodialysis (HD) patients. | Journal of military pharmaco-medicine no5-2017 RELATION BETWEEN PLASMA HOMOCYSTEINE, FOLATE, VITAMIN B12 LEVELS WITH BLOOD PRESSURE, RESIDUAL RENAL FUNCTION, ANEMIA, DIALYSIS DURATION AND SERUM ALBUMIN IN MAINTENANCE HEMODIALYSIS PATIENTS Diem Thi Van*; Hoang Trung Vinh* Summary Objectives: To analyze relation between levels of plasma homocysteine (Hcy), folate, vitamin B12 with blood pressure (BP), residual renal function (RRF), anemia, dialysis duration and serum albumin in hemodialysis (HD) patients Subjects and methods: 112 HD patients were clinically and subclinically examined including measurements of plasma Hcy, folate and vitamin B12 levels. Assessments of Hcy, folate and vitamin B12 levels in HD patients were based on their levels in 56 healthy individuals. Results: Patients with unaccepted BP control had higher level of plasma Hcy and rate of hyperhomocysteinemia but a lower rate of vitamin B12 deficiency than those with accepted BP control. Patients with RRF had significantly lower rate of hyperhomocysteinemia and higher rate of vitamin B12 decrease than patients without RRF. Levels of plasma Hcy, folate and vitamin B12 in HD patients were not significantly relative to anemia. With dialysis duration, folate was negatively correlated (r = ; p 1 month. * Excluded criteria for the study group: 210 - Patients were treated by HDF online method. - Patients with currently serious complications or malabsorption syndrome. 2. Methods. * Study design: a cross-sectional description, in comparison with control group. * Study contents: - For the study group: We collected history of disease, performed clinical examinations and laboratory tests. Patients were asked to provisionally stop using folate and vitamin B12-containing drugs at least one day before taking plasma homocysteine, folate and vitamin B12 tests. Blood sample was drawn under fasting condition and before the first dialysis session of the week. Plasma Hcy, folate and vitamin B12 levels were measured