tailieunhanh - Investigation of bone mineral density in female patients with rheumatoid arthritis

Objectives: To investigate the changes of bone mineral density (BMD) and their relationship with some risk factors in female patients with rheumatoid arthritis (RA). Subjects and methods: A cross-sectional descriptive study on 49 female patients with RA, who had average age of ± years. | Journal of military pharmaco-medicine INVESTIGATION OF BONE MINERAL DENSITY IN FEMALE PATIENTS WITH RHEUMATOID ARTHRITIS Nguyen Minh Phuong*; Le Van Quyet**; Nguyen Ngoc Chau*** SUMMARY Objectives: To investigate the changes of bone mineral density (BMD) and their relationship with some risk factors in female patients with rheumatoid arthritis (RA). Subjects and methods: A cross-sectional descriptive study on 49 female patients with RA, who had average age of ± years. BMD at lumbar spine and neck of femur were measured by a DEXA method (Hologic QDR4500 Elite). Tender and swollen joints were examined; also CRP, hemoglobin, anti-CCP levels, and erythrocyte sedimentation rates (ESR) were measured; then DAS28 CRP and DAS28 ESR were calculated. Results: The mean of BMD of lumbar spine and neck of femur were ± and ± g/cm2, respectively; mean BMD and BMD of categories of age from 40 to 70 years old were lower than those of Vietnamese woman with the same age. The results of multivariant regression analysis showed that there were corelations between BMD and age, BMI, DAS28 CRP, DAS28 ESR, and hemoglobin levels; however, among five variants, the corelation between BMD and age was the strongest, with R = , p = , and the age also was considered as an independent factor to predict BMD of neck of femur. BMD of lumbar spine was insignificantly inversely associated with DAS28 CRP and hemoglobin levels. BMD of neck of femur was also insignificantly inversely associated with DAS28 CRP. Conclusion: These results suggested that BMD of lumbar spine and neck of femur reduces in female patients with RA. There was a strongest correlation between BMD and age and the age could be an independent factor to predict BMD in neck of femur. * Keywords: Rheumatoid arthritis; Bone mineral density; Osteoporosis. INTRODUCTION Rheumatoid arthritis (RA) is a chronic inflammatory disease mainly in synovium, causing destruction of the edge of joint bones, .