tailieunhanh - Platelet disorders in acute decompression sickness in rabbits

Objectives: To determine changes of platelet indexes and their correlations to severity of decompression sickness (DCS) in a rabbit model. Subjects and methods: Thirty-one rabbits were included in the experiment, they were compressed to hyperbaric 6 ATA (atmosphere absolute) for 5 hours, and then decompressing at a speed equal to 10 meters/min to surface. | Journal of military pharmaco-medicine No7-2017 PLATELET DISORDERS IN ACUTE DECOMPRESSION SICKNESS IN RABBITS Cao Hong Phuc*; Dang Quoc Bao*; Nguyen Minh Phuong* Nguyen Van Tuyen*; Nguyen Thi Hien Hanh* Nguyen Khanh Van*; Nguyen Tung Linh* SUMMARY Objectives: To determine changes of platelet indexes and their correlations to severity of decompression sickness (DCS) in a rabbit model. Subjects and methods: Thirty-one rabbits were included in the experiment, they were compressed to hyperbaric 6 ATA (atmosphere absolute) for 5 hours, and then decompressing at a speed equal to 10 meters/min to surface. They were observed at 30-min before and after the DSC-induced experiment. Blood samples were taken at rabbits’ death time or 30 min after decompression. Platelet-related indexes included platelet count, mean platelet volume (MPV), the percentage change of platelet count, severity score, paralytic score and survival time. Results: At 30-min after decompression, platelet count decreased significantly (p *** Post (b) ± ± ± *** Post (b) ± ± ± (**: Wilcoxon Ranks test; ***: Mann Whitney U test) This table showed no change of MPV at 30 min in post-experiment (p > ), but a mild increase in the severe group and a decrease in the mild-medium group. In postexperiment, MPV was different between the severe and mild-medium groups (p < ). 2. Platelet counts, severity scores, and survival time. The platelet counts in three groups of severity scores were shown in figure 1 and their correlation with survival time shown in figure 2. Figure 1: Platelet counts from three groups of paralytic scores in pre- and post-experiments. 24 Journal of military pharmaco-medicine no7-2017 Figure 1 indicated a significant decrease in platelet count in the severe group (p < ), and also a difference in this index among three groups of severity scores, at 30 min post-experiment. Figure 2: