tailieunhanh - Investigation of serum IL-1β level in patients with knee osteoarthritis

Objects: To evaluate serum level of IL-1β and a relation between the IL-1β and inflammatory factors in patients with knee osteoarthritis (OA). Subjects and methods: 43 patients were diagnosed with knee osteoarthritis and 40 healthy individuals were selected. The study had focused on gender, age, VAS (Visual Analog Scale) index, ESR (Erythrocyte Sedimentation Rate) and serum level of IL-1β. | Journal of military parmaco-medicine n07-2017 INVESTIGATION OF SERUM IL-1β LEVEL IN PATIENTS WITH KNEE OSTEOARTHRITIS Nguyen Ngoc Chau*; Doan Van De* SUMMARY Objects: To evaluate serum level of IL-1β and a relation between the IL-1β and inflammatory factors in patients with knee osteoarthritis (OA). Subjects and methods: 43 patients were diagnosed with knee osteoarthritis and 40 healthy individuals were selected. The study had focused on gender, age, VAS (Visual Analog Scale) index, ESR (Erythrocyte Sedimentation Rate) and serum level of IL-1β. Results: - The mean level of IL-1β in the knee OA patients was higher than that in control group ( ng/mL vs. ng/mL; p Male 7 () 7 () > ). The most common age group was 50 - 59 (). This result was also consistent with a previous study by Vu Dinh Chinh, in which the mean age of patients with osteoarthritis was 50 - 60 [1]. Table 3: Pain levels (VAS) and erythrocyte sedimentation rate (ESR) of studied objects. Indexes Patients (n = 43) Control group (n = 40) ± (-) ± ± Pain levels (VAS) Erythrocyte sedimentation rate (ESR) - mm p Male (n = 7) Female (n = 33) p ± ± > IL-1β (pg/mL) ± Median value of IL-β concentration ± < IL-1β is one of the typical cytokines of the inflammatory reaction that occurs in the body. Previous studies have also shown that there has been a certain role of inflammatory reaction in the pathogenesis of osteoarthritis [4, 8, 9]. In our study, patient group had markedly high concentration of IL-1β than the control group (mean concentration: ± pg/mL vs. ± median concentration: pg/mL vs. pg/mL). 140 Journal of military phrmaco-medicine nO7-2017 This is the new data in patients with knee osteoarthritis who are Vietnamese. This result had further contribution of evidence to the role of IL-1β in inflammatory reactions in the .