tailieunhanh - Outcomes of microdissection testicular sperm extraction in non obstructive azoospermic pattients

Objectives: To evaluate the changes of successful retrieval of sperm and the relation of its sperm retrieval rate with patients' characteristics. Subjects and methods: This study was carried out on 50 patients with non-obstructive azoospermia who underwent micro-TESE from June 2016 to July 2017 at Centre for Assisted Reproduction, Vietnam Military Medical University. | Journal of military pharmaco-medicine no1-2018 OUTCOMES OF MICRODISSECTION TESTICULAR SPERM EXTRACTION IN NON-OBSTRUCTIVE AZOOSPERMIC PATTIENTS Vu Thi Thu Trang*; Nguyen Dinh Tao** Quan Hoang Lam**; Trinh The Son** SUMMARY Objectives: To evaluate the changes of successful retrieval of sperm and the relation of its sperm retrieval rate with patients' characteristics. Subjects and methods: This study was carried out on 50 patients with non-obstructive azoospermia who underwent micro-TESE from June 2016 to July 2017 at Centre for Assisted Reproduction, Vietnam Military Medical University. Medical records were reviewed for the results of the mean patients' age, duration of infertility, testicular volume, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels, AZF microdeletions analysis and the overall sperm retrieval rate. Results: The mean patients' age was ± years, duration of infertility ± years, testicular volume ± mL. Six patients (12%) had AZF microdeletions. Patients' age, testicular size, serum LH, testosterone and AZF microdeletions showed no significant impact on sperm retrieval rate. FSH levels differed significantly in patients whose sperm is retrieved versus patients whose sperm is not retrieved with micro TESE. The overall sperm retrieval rate was 32%.Conclusions: Microdissection testicular sperm extraction (micro - TESE) has a high sperm retrieval rate. FSH levels may predict the changes of obtaining spermatozoa in patients with non-obstructive azoospermia. * Keywords: Microdissection testicular sperm extraction; Non-obstructive azoospermia; Sperm retrieval. INTRODUCTION Azoospermia is defined as the absence of spermatozoa in the ejaculate after the assessment of centrifuged semen on at least two occasions. It is observed in 1% of the general population and in 10 - 15% of infertile men [1]. Surgical sperm retrieval and intracytoplasmic sperm injection (ICSI) have revolutionized the management .