tailieunhanh - 3D cytotoxic and histon deacetylase (HDAC) inhibitory activities of triterpenoids isolated from leaves of Viburnum sambucinum

In this study, we describe 3D cytotoxic and histone deacetylase (HDAC) inhibitory activities of two nordammarane triterpenoids hupehenol D (1) and 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanrane (2) isolated from the leaves of Viburnum sambucinum. The result showed that (1) and (2) exhibited a strong activity against 3D models of LLC cell line with the IC50 value of µM and µM, respectively. Compound 1 weakly inhibited activity of enzyme HDAC with the IC50 of ± M while compound 2 exhibited no effect on HDAC at 25 M. | Vietnam Journal of Chemistry, International Edition, 55(6): 724-728, 2017 DOI: 3D cytotoxic and histon deacetylase (HDAC) inhibitory activities of triterpenoids isolated from leaves of Viburnum sambucinum Nguyen Thanh Tra1*, Nguyen Thi Thu Ha1, Ba Thi Cham1, Le Thi Tu Anh1, Do Thi Thao3, Nguyen Thi Nga3, Doan Thi Mai Huong2, Pham Van Cuong2 1 Institute of Chemistry,Vietnam Academy Science and Technology (VAST) 2 Institute of Marine Biochemistry, VAST 3 Institute of Biotechnology, VAST Received 14 June 2017; Accepted for publication 29 December 2017 Abstract The plant Viburnum sambucinum has been known under the local name “Vót dạng cơm cháy” belongs to Viburnum genus, a member of the Caprifoliaceae family. Many plants of Viburnum genus are well known for their medicinal properties and are used in the folk medicine for the treatment of various diseases. A variety of structures have been reported from the plants of the genus, such as diterpenes, triterpenes, iridoids, sesquiterpenes, flavonoids, etc. In this study, we describe 3D cytotoxic and histone deacetylase (HDAC) inhibitory activities of two nordammarane triterpenoids hupehenol D (1) and 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanrane (2) isolated from the leaves of Viburnum sambucinum. The result showed that (1) and (2) exhibited a strong activity against 3D models of LLC cell line with the IC50 value of µM and µM, respectively. Compound 1 weakly inhibited activity of enzyme HDAC with the IC50 of ± M while compound 2 exhibited no effect on HDAC at 25 M. Keywords. Viburnum sambucinum, Caprifoliaceae, hupehenol D (1), 12β-hydoxy-3,15-dioxo-20,21,2223,24,25,26,27-octanordammanrane (2), 3D cytotoxic, HDAC inhibitory activity. 1. INTRODUCTION Cancer is one of the leading cause of death and globally the numbers of new cases of cancer are increasing gradually [1]. Current estimates from the American Cancer Society indicate that 7 .