tailieunhanh - Sterols from stems of Momordica cochinchinesis (Lour.) Spreng
Three known sterols, polypodine B (1), (22E,24R)-24-methylcholesta-2,22-diene-3β,5α,6β-triol (2) and chondrillasterol (3) were isolated from the stems of Momordica cochinchinesis (Lour.) Spreng. Their chemical structures were successfully determined using NMR and ESI-MS analysis as well as in comparison with the reported data. All compounds were reported from Momordica genus for the first time. | Vietnam Journal of Chemistry, International Edition, 55(5): 606-610, 2017 DOI: Sterols from stems of Momordica cochinchinesis (Lour.) Spreng Nguyen Thi Mai1, Phan Van Kiem2*, Vu Kim Thu3 1 University of Transport and Communications 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology 3 Hanoi University of Mining and Geology Received 15-3-2017/12-8-2017; Accepted for publication 20 October 2017 Abstract Three known sterols, polypodine B (1), (22E,24R)-24-methylcholesta-2,22-diene-3β,5α,6β-triol (2) and chondrillasterol (3) were isolated from the stems of Momordica cochinchinesis (Lour.) Spreng. Their chemical structures were successfully determined using NMR and ESI-MS analysis as well as in comparison with the reported data. All compounds were reported from Momordica genus for the first time. Keywords. Momordica cochinchinesis, Cucurbitaceae, steroid. 1. INTRODUCTION Momordica genus belongs to Cucurbitaceae family, including 60 species. In Vietnam, there are three species, comprising of M. charantia, M. cochinchinensis, and M. grosvenori. M. cochinchinensis is a dioecious species with yellow flowers, green globe fruits turn orange and red when ripened [1]. The main ingredient of M. cochinchinensis oil is β-carotene, which is used to treat diseases related to vitamin A as slow growth in children, dry eyes, night blindness, tired and anorexic people. Additionally, M. cochinchinensis oil is used in the treatment of the wound and burns. The seeds are used to treat abscess, mumps, swelling breast, engorgement, hemorrhoids and pile. The roots are bitter, cool thus used for preventing lowtemperature effects, diuretics [1]. The chemical studies of M. cochinchinensis indicated the presence of triterpenoids [2], carotenoids [3]. These compounds showed the anti-inflammatory [2], stomach ulcers, and wound healing activities [4]. In this paper, we report the isolation, structural elucidation of one ecdysterone and .
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