tailieunhanh - Lignans isolated from the ethyl acetate extract of Knema pachycarpa fruit

Knema is a genus of tropical evergreen trees of the family Myristicaceae found in South East Asian countries such as Vietnam, Thailand, and Malaysia. In this paper, four lignans, (+)-pinoresinol (1),(+) epi-pinoresinol (2), piperitol (3), and pluviatilol (4), were isolated from the ethyl acetate extract of the fruit of Knema pachycarpa, an indigenus tree in Vietnam. The chemical structures were determined by spectroscopic data and comparison with the reported literature. These compounds were isolated from Knema genus for the first time. | Vietnam Journal of Chemistry, International Edition, 55(4): 406-410, 2017 DOI: Lignans isolated from the ethyl acetate extract of Knema pachycarpa fruit To Hai Tung1, Cao Thi Hue1, Tran Huu Giap1,2, Ha Thi Thoa1, Nguyen Anh Dung1, Nguyen Thi Minh Hang1,2, Nguyen Van Hung1,2, Le Nguyen Thanh1,2,* 1 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST) 2 Graduate University of Science and Technology, VAST Received 28 September 2016; Accepted for publication 28 August 2017 Abstract Knema is a genus of tropical evergreen trees of the family Myristicaceae found in South East Asian countries such as Vietnam, Thailand, and Malaysia. In this paper, four lignans, (+)-pinoresinol (1),(+) epi-pinoresinol (2), piperitol (3), and pluviatilol (4), were isolated from the ethyl acetate extract of the fruit of Knema pachycarpa, an indigenus tree in Vietnam. The chemical structures were determined by spectroscopic data and comparison with the reported literature. These compounds were isolated from Knema genus for the first time. Keywords. Knema pachycarpa de Wilde, (+)-Pinoresinol, (+)-Epi-pinoresinol, Piperitol, Pluviatilol. 1. INTRODUCTION Knema is a genus of tropical evergreen trees of the family Myristicaceae found in South East Asian countries such as Vietnam, Thailand, and Malaysia. At least 13 species are found in Vietnam, where they are commonly known as “mau cho” referring to the red resin secreted in the bark [1]. Traditionally, Knema species have been used to treat sore, pimples, cancers and skin diseases. The genus Knema contains variety of natural compounds including cardanols, flavonoids, acetophenones, lignans, acylphloroglucinols, acylresorcinols, and anacardic acids [2-4]. Knema pachycarpa de Wilde “Mau cho trai day” is an indigenus tree in Vietnam and the chemical study of this Knema species has not been reported. In this paper, we report the isolation of 4 lignan compounds from the ethyl acetate .