tailieunhanh - 5-fluorouracil encapsulated CS-mPEG nanogels for controlling drug release

The purpose of this study is to synthesize and characterize poly (ethylene glycol) methyl ether (mPEG) conjugated chitosan (CS), mPEG-CS, at different ratios of 5-Fluorouracil (5-FU) delivery (5-FU-loaded mPEG-CS). The chemical cross-linking of these polymers were prepared by using 4-Nitrophenyl chloroformate reagent. The obtained mPEG-CS was characterized by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance (1H NMR) spectroscopy. | Vietnam Journal of Chemistry, International Edition, 55(4): 446-449, 2017 DOI: 5-fluorouracil encapsulated CS-mPEG nanogels for controlling drug release Nguyen Dai Hai Institute of Applied Materials Science, Vietnam Academy of Science and Technology Received 29 December 2016; Accepted for publication 28 August 2017 Abstract The purpose of this study is to synthesize and characterize poly (ethylene glycol) methyl ether (mPEG) conjugated chitosan (CS), mPEG-CS, at different ratios of 5-Fluorouracil (5-FU) delivery (5-FU-loaded mPEG-CS). The chemical cross-linking of these polymers were prepared by using 4-Nitrophenyl chloroformate reagent. The obtained mPEG-CS was characterized by Fourier transform infrared (FTIR) and proton nuclear magnetic resonance ( 1H NMR) spectroscopy. The 5-FU-loaded mPEG-CS particles were nearly spherical in shape with a mean diameter of nm, determined by transmission electron microscopy (TEM). In addition, the entrapment efficiency of 5-FU was approximately 10 %. Whereas the encapsulation efficiency and loading capacity were independent of different molar ratios of mPEG, there was one factor that particularly stands out, which is 5-FU release behavior. These results indicated that mPEG-CS nanogels present the potential for controlled release of 5-FU working as a delivery system in cancer therapy. Keywords. Poly(ethylene glycol) methyl ether, chitosan, 5-fluorouracil, nanogels, drug delivery system. 1. INTRODUCTION Drug delivery system (DDS) has been an outstanding subject of studying and developing as an original method to control drug release in the blood stream for reducing toxic side-effects in patients. DDS tends to particularly localize and target the drug within desired therapeutic range to expected tissue and cells while maintaining the systemic level of drugs [1]. In order to reach these intentions, nanomaterials (NMs) possess enormous advantages: i) protecting sensitive drug molecules .

• Hoá học
• Vietnam Journal of Chemistry
• 5 fluorouracil encapsulated CS mPEG nanogels
• Controlling drug release
• Characterize poly methyl ether
• Fourier transform infrared
• Proton nuclear magnetic resonance
• Membrane processes and their potential applications
• Fresh water provision in Vietnam
• Mature and emerging membrane processes destined
• Pressure driven filtration
• Anticaries activity of mangiferin
• Mangifera indica leaves in Vietnam
• Vietnamese Mangifera indica leaves
• Acid production and biofilm formation
• Mangiferin possesses moderate anticaries activity against
• Screening for the main triterpenic acids
• Centella asiatica samples
• North and South of Vietnam
• The main triterpenic acids
• Both triterpenic acids
• Nanosilica chitosan hybrid on leaf blast
• Blight diseases of rice in Vietnam
• Particularly for rice
• The leaf blast disease index
• Fissistigma oldhamii
• Growing in Vietnam
• Influence of operating conditions and membrane fouling
• Water flux during seawater desalination
• Air gap membrane distillation
• Seawater AGMD desalination
• Remote communities in Vietnam
• Vietnam journal of earth sciences
• Fluid characteristics from shallow magmatic environments
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• Shallow magmatic environments
• Fluid inclusions show the same chemistry
• Journal of Chemistry
• Further chemical constituents
• Scoparia dulcis L
• Scrophulariaceae originating
• The MeOH extract
• Study on change of color
• High density polyethylene organo modified calcium carbonate composites exposed naturally
• Dong Hoi Quang Binh
• Modified calcium carbonate
• Synthesis and electrochemical performance of MoO2 graphene nanomaterials
• Synthesis and electrochemical performance
• Anode for lithium ion battery
• Molybdenum dioxide graphene composites
• Indicated graphene composition
• Phytochemical and cytotoxic investigations
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• Algal cyanobacterial symbioses
• Searching cytotoxic compound
• Preparation of some new benzo[d]thiazole derivatives
• New benzo[d]thiazole derivatives
• Both phenolic hydroxyl group
• Mass spectral analyses
• Quantum chemical computation insight
• The donor acceptor bond interaction
• Silver complexes with tetrylene
• N heterocyclic tetrylene
• Bond dissociation energy
• Quantum chemical calculations
• Preparation and characterization of nanosilica from rice husk ash
• Chemical treatment combined with calcination
• Rice husk ash
• X ray diffraction
• X ray spectroscopy
• Large scale fabrication
• Colloidal nano sized CuCl solution
• High concentration for using as fungicide for plant
• Fungicide for plant
• The effect of combustion temperature
• Low tar gas production
• Oxygen enriched air
• The producer gas
• The lower heating value
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• Heterogeneous fenton like reaction
• Fe2O3 SiO2 composite
• Scanning electron microscopy
• Thermokinetic study of the isomerization of isocyanic acid
• The isomerization of isocyanic acid
• Kinetics and thermochemistry
• Rice Ramsperger KasselMarcus
• Synthesis of new hemiasterlin derivatives
• α
• β unsaturated carbonyl thiophene groups in fragment A
• New hemiasterlin derivatives
• The high reactivity
• Mg Al MoO4 layered double hydroxides
• Catalysts for the oxidation of styrene
• The oxidation of styrene
• The synthesized solids showed the layered hydroxide structure
• Two cycloartanes type triterpenoid from Homonoia riparia Lour
• Two cycloartanes type triterpenoid
• Homonoia riparia Lour
• Various chromatography methods
• Study on adsorption of phosphate from aqueous solution
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• X ray diffraction
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• Terpenoids from the leaves
• Acute myeloid leukemia
• The basic of spectroscopic methods
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• Small degree of site interchange
• The tetrahedral sites