tailieunhanh - Effect of Ich Tri Vuong capsule on plasma lipid level and degree of atherosclerosis in cholesterol fed- rabbits

Ich Tri Vuong capsules (ITV) (components Ginkgo biloba, Radix Salviae miltiorrhi zae, Radix Astragali membranacei and Radix Angelicae sinensis) is used to treat diseases caused by atherosclerosis. This study was designed to assess the effects of ITV on plasma levels of total cholesterol, triglyceride, Low-density lipoprotein (LDL). | JOURNAL OF MEDICAL RESEARCH EFFECT OF ICH TRI VUONG CAPSULE ON PLASMA LIPID LEVEL AND DEGREE OF ATHEROSCLEROSIS IN CHOLESTEROL-FED RABBITS Le Thi Minh Phuong1, Nguyen Tran Thi Giang Huong1, Do Thi Phuong1, Nguyen Thi Tuyet Nga2 1 Faculty of Traditional Medicine, Hanoi Medical University, 2 Military Institute of Traditional Medicine Ich Tri Vuong capsules (ITV) (components Ginkgo biloba, Radix Salviae miltiorrhi zae, Radix Astragali membranacei and Radix Angelicae sinensis) is used to treat diseases caused by atherosclerosis. This study was designed to assess the effects of ITV on plasma levels of total cholesterol, triglyceride, Low-density lipoprotein (LDL), High-density lipoprotein (HDL) and degrees of aorta atherosclerosis in rabbits with induced atherosclerosis by high cholesterol feeds. 50 New Zealand White rabbits were divided into 5 groups, 10 per group. Experiment conditions were carried out for 8 weeks. Normal group: fed with water 2 ml/kg/day. Control group: fed cholesterol g/kg/day + water 2 ml/kg. Atorvastatin group: fed cholesterol g/kg/day + Atorvastatin 5 mg/kg/day. ITV dose 1 group (60 mg/kg/day): fed cholesterol g/kg/day+ ITV 60 mg/kg/day. ITV dose 2 group (180 mg/kg/day): fed cholesterol g/kg/ngày + ITV 180 mg/kg/day. The results suggest that Ich Tri Vuong 180 mg/kg/day may decrease plasma levels of Total cholesterol and LDL and reduce atherosclerotic lesions of rabbits with induced atherosclerosis by high cholesterol feeds when compared to control group. These effects were equivalent to Atorvastatin 5 mg/kg/day and better than Ich Tri Vuong 60mg/kg/day. There were no significant differences in HDL and Triglyceride of ITV groups when compared to control group. Key works: Ich Tri Vuong, Atherosclerosis, plasma lipid I. INTRODUCTION Atherosclerosis is a disease of large and medium arteries. Lesions begin as fatty streaks, caused by massive accumulation of LDL oxidative product [1; 2] with high blood cholesterol LDL is increased