tailieunhanh - Fabrication of biodegradable polyester microspheres by electrospraying methods for drug carrier application

This research investigated the effects of polymer concentration, molecular weight polymer and type of polymer on the morphology of electrosprayed microparticles by Scanning Electron Microscopy. Electrospraying process has been studied to produce nano- and micro- particles for drug carrier application because of high loading capacity and high encapsulation efficiency. | Journal of Science and Technology 54 (5A) (2016) 99-106 FABRICATION OF BIODEGRADABLE POLYESTER MICROSPHERES BY ELECTROSPRAYING METHODS FOR DRUG CARRIER APPLICATION Nguyen Vu Viet Linh1, 2, Huynh Dai Phu1, 2, * 1 Faculty of Materials Technology, Ho Chi Minh City University of Technology, VNU – HCM, 268 Ly Thuong Kiet Street, Ward 14, District 10, Ho Chi Minh City 2 National Key Laboratory of Polymer and Composite Materials, Ho Chi Minh City University of Technology, VNU – HCM, 268 Ly Thuong Kiet, Ward 14, District 10, Ho Chi Minh City * Email: hdphu@ Received: 31 July 2016; Accepted for publication: 3 December 2016 ABSTRACT This research investigated the effects of polymer concentration, molecular weight polymer and type of polymer on the morphology of electrosprayed microparticles by Scanning Electron Microscopy. Electrospraying process has been studied to produce nano- and micro- particles for drug carrier application because of high loading capacity and high encapsulation efficiency. Controlling morphology and structure of electrosprayed particles can decide the release of drug from these particles. Particles were hollow and wrinkled semi-spheres as using low polymer concentration while wrinkled spheres as using higher polymer concentration. The electrosprayed particles obtained spherical morphology when the polymer concentration is high enough to generate significant chain entanglements. The results also indicated that high molecular weight polymer could produce spherical microspheres, even with low polymer concentration. The electrospraying process fabricated the microspheres from biodegradable PLA and PCL for drug carrier application. Keywords: electrospray, microparticle, morphology, microsphere. 1. INTRODUCTION The biodegradable polyesters, such as Polylactic acid (PLA) and Polycaprolactone (PCL), were used to produce drug loaded microparticles by several methods like micro-emulsion, solvent evaporation, spray drying, ionic gelation, etc. .