tailieunhanh - Water-soluble components of ancistrocladus cochinchinensis

Using various chromatography methods, a saponin, ginsenoside Rg1 (1), and three phenolic glycosides, tortoside A (2), phlorizin (3), and 4-hydroxy-2-methoxyphenyl-6-Osyringyl-β-D-glucopyranoside (4) were isolated from the water-soluble fraction of Ancistrocladus cochinchinensis. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses and comparison with those reported in the literature. Compound 1 was reported from A. cochinchinensis for the first time. | Vietnam Journal of Science and Technology 55 (6) (2017) 683-689 DOI: WATER-SOLUBLE COMPONENTS OF Ancistrocladus cochinchinensis Le Quynh Lien1, *, Nguyen Thi Cuc1, Hoang Le Tuan Anh2, Tran My Linh1, Vu Huong Giang1, Ninh Khac Ban1, Nguyen Chi Mai1, Trieu Quy Hung3, Pham Thi Hai Yen4, Phan Van Kiem1, * 1 2 Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet Cau Giay, Ha Noi Mientrung Institute for Scientific Research, Vietnam Academy of Science and Technology 3 4 Faculty of Natural Sciences, Hung Vuong University, Viet Tri, Phu Tho Thanh Hoa Sports and Physical Education College, Ngoc Trao, Thanh Hoa * Email: phankiem@ Received: March, 2017; Accepted for Publication: xxx, 2017 Abstract. Using various chromatography methods, a saponin, ginsenoside Rg1 (1), and three phenolic glycosides, tortoside A (2), phlorizin (3), and 4-hydroxy-2-methoxyphenyl-6-Osyringyl-β -D-glucopyranoside (4) were isolated from the water-soluble fraction of Ancistrocladus cochinchinensis. Their structures were elucidated by 1D- and 2D-NMR spectroscopic analyses and comparison with those reported in the literature. Compound 1 was reported from A. cochinchinensis for the first time. Keywords: Ancistrocladus cochinchinensis, ginsenoside Rg1, tortoside A, phlorizin. 1. INTRODUCTION Ancistrocladus cochinchinensis is an endemic species of Viet Nam. It has been used in folk medicines with diruric, anti-febrile, and anti-phlogistic properties [1]. They are rich in naphtylisoquinoline alkaloids (NIQs) which exhibited unique chemical structure, specific biological activities and hence recently received much interests of medicinal chemists. They have been demonstrated to exhibit excellent, specific on anti-malarial, anti-protozoal, insecticidal, antimicrobial, anti-proliferative and anti-HIV activities [2 - 7]. In this paper, we describe the isolation and structural elucidation of four compounds belonging to