tailieunhanh - Structure elucidation and cytotoxic activity of attenuatoside B-1, planciside A, and culcitoside C2 from the starfish acanthaster planci

Detailed analysis of the 1D and 2D NMR data and comparison with the reported values, the structures of attenuatoside B-1 (1), planciside A (2), and culcitoside C2 (3) from the starfish Acanthaster planci were clearly elucidated. Culcitoside C2 (3) showed weak cytotoxicity against five human cancer cell lines including HepG2, KB, LNCaP, MCF7, and SK-MEL-2. | Vietnam Journal of Science and Technology 56 (1) (2018) 1-6 DOI: STRUCTURE ELUCIDATION AND CYTOTOXIC ACTIVITY OF ATTENUATOSIDE B-1, PLANCISIDE A, AND CULCITOSIDE C2 FROM THE STARFISH ACANTHASTER PLANCI Le Thi Vien1, Tran Thi Hong Hanh1, Phan Thi Thanh Huong1, Do Thi Thao2, Nguyen Van Thanh1, Nguyen Xuan Cuong1, *, Nguyen Hoai Nam1 1 Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi 2 Institute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi * Email: cuongnx@ Received: 8 February 2017; Accepted for publication: 9 November 2017 Abstract. Detailed analysis of the 1D and 2D NMR data and comparison with the reported values, the structures of attenuatoside B-1 (1), planciside A (2), and culcitoside C2 (3) from the starfish Acanthaster planci were clearly elucidated. Culcitoside C2 (3) showed weak cytotoxicity against five human cancer cell lines including HepG2, KB, LNCaP, MCF7, and SK-MEL-2. Keywords: Acanthaster planci, starfish, steroid glycoside, cytotoxic activity. Classification numbers: ; ; . 1. INTRODUCTION Steroid glycosides are a class of wide-spread natural products having either terrestrial or marine origins. The marine steroid glycosides were mainly isolated from invertebrates such as echinoderms, sponges, and soft corals. Among marine invertebrates, starfish is the richest source of steroid glycosides, at that any studied species contains a wide diversity of this kind of compounds [1]. The crown-of-thorns starfish Acanthaster planci is distributed in tropical waters of the Indian and Pacific Oceans, Red Sea, Australia, Seychelles, Madagascar, Philippines, and abundantly found in Vietnam sea. Prior investigations demonstrated that steroids, steroid glycosides, asterosaponins, carotenoids, ceramides, cerebrosides, and gangliosides are main constituents of this starfish [2]. Recently, investigations on this species (collected in Van Phong bay, Khanh Hoa .