tailieunhanh - The isolated compounds from the twigs of Morus alba L. in Dong Thap

From the ethyl acetate extract of the twigs of Morus alba L. (Moraceae) growing in Dong Thap, Vietnam, a pentacyclic triterpenoid, β-amyrin-β-D-glucopyranoside (1), a Diels – Alder type adduct, mulberrofuran G (2), a benzofuran, moracin M (3) and a prenylated flavonoid, kuwanon G (4) were isolated through repeated silica gel column chromatography. Their structures were identified by physicochemical and spectrometric methods. | Journal of Science and Technology 54 (4) (2016) DOI: THE ISOLATED COMPOUNDS FROM THE TWIGS OF MORUS ALBA L. IN DONG THAP Bui Thi Minh Nguyet1, *, Tran Huynh Nguyen Khanh2 1 2 Faculty of Chemistry, Dong Thap University,783, Pham Huu Lau street, Ward 6, Cao Lanh City, Dong Thap province, Vietnam Dong Thap Technology and Science Department, 3, Vo Truong Toan street, Ward 1, Cao Lanh City, Dong Thap province, Vietnam * Email: nguyetdhdt@ Received: 29 October 2015; Accepted for publication: 30 March 2016 ABSTRACT From the ethyl acetate extract of the twigs of Morus alba L. (Moraceae) growing in Dong Thap, Vietnam, a pentacyclic triterpenoid, β -amyrin-β-D-glucopyranoside (1), a Diels – Alder type adduct, mulberrofuran G (2), a benzofuran, moracin M (3) and a prenylated flavonoid, kuwanon G (4) were isolated through repeated silica gel column chromatography. Their structures were identified by physicochemical and spectrometric methods. Keywords: β-amyrin-β-D-glucopyranoside, mulberrofuran G, moracin M, kuwanon G, Morus alba. 1. INTRODUCTION The genus Morus (Moraceae) comprises about a dozen of species which are widely distributed in India, China, Japan, North Africa, Arabia, South Europe, etc. [1]. Five species were found in Vietnam [2]. White mulberry (Morus alba L.) is widely cultivated in many Asian countries where the leaves are used as the best feed for silkworms because they contain many nutritional components [3]. Almost all parts of this plant is used in folk medicine in Vietnam as well as in China, Korea and Japan [4]. In recent studies many potentially active compounds have been isolated from Morus alba L. including flavonoids [5], benzofurans and stilbenoid [6], lignans [7], alkaloids and amino acids [8], coumarins [9], and triterpenoids [10]. In this study, we report the isolation of four compounds from twigs of Morus alba in Dong Thap. Their spectroscopic data were compared with previously reported ones to .