tailieunhanh - Lavonoids and triterpenoids from callistemon citrinus and their inhibitory effect on no production in lps stimulated raw264.7 macrophages

Phytochemical investigation of the leaves and stems of Callistemon citrinus (Curtis) Skeels led to the isolation of 12 flavonoid and triterpenoid compounds, including one new flavonoid, callistine A (1) and six known flavonoids, 6,7- dimethyl-5,7-dihydroxy-4'-methoxy flavone (2), astragalin (3), quercetin (4), catechin (5), eucalyptin (6), and 8-demethyleucalyptin (7), along with 5 known triterpenoids, 3-β-acetylmorolic acid (8), 3β-hydroxy-urs-11-en-13(28)-olide (9), betulinic acid (10), diospyrolide (11) and ursolic acid (12). | Journal of Science and Technology 54 (2) (2016) 214-223 DOI: FLAVONOIDS AND TRITERPENOIDS FROM CALLISTEMON CITRINUS AND THEIR INHIBITORY EFFECT ON NO PRODUCTION IN LPS-STIMULATED MACROPHAGES Nguyen Manh Cuong1, Pham Ngoc Khanh1, Ho Viet Duc2, Tran Thu Huong1, Youn-Chul Kim3, Pham Quoc Long1, Young Ho Kim4 1 Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi 2 Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Vietnam 3 College of Pharmacy, Wonkwang University, Iksan 570-749, Korea 4 College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea * Email: nmcuong_inpc@ Received: 11 August 2015; Accepted for publication: 2 January 2016 ABSTRACT Phytochemical investigation of the leaves and stems of Callistemon citrinus (Curtis) Skeels led to the isolation of 12 flavonoid and triterpenoid compounds, including one new flavonoid, callistine A (1) and six known flavonoids, 6,7- dimethyl-5,7-dihydroxy-4'-methoxy flavone (2), astragalin (3), quercetin (4), catechin (5), eucalyptin (6), and 8-demethyleucalyptin (7), along with 5 known triterpenoids, 3-β-acetylmorolic acid (8), 3β-hydroxy-urs-11-en-13(28)-olide (9), betulinic acid (10), diospyrolide (11) and ursolic acid (12). Their chemical structures were determined by analysis of their 1D- and 2D-NMR and HR-MS data. All isolated compounds were examined for their inhibitory activity against LPS-activated NO production in macrophage cells. Among them, quercetin (4) and 3β-hydroxy-urs-11-en-13(28)-olide (9) showed the most potent activities. Keywords: Callistemon macrophage. citrinus (Curtis) Skeels, flavonoid, triterpenoid, 1. INTRODUCTION Nitric oxide (NO) is an important molecule. It acts as a defense factor against invading bacterial pathogens and is an essential element in the regulation of immune reactions [1]. .

• Hoá học
• Journal of Science and Technology
• Lavonoids and triterpenoids
• Inhibitory effect on no production
• lps stimulated raw264
• 7 macrophages
• Allistemon citrinus (Curtis) Skeels
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