tailieunhanh - Synthesis of some 2-amino-4,6-diarylpyrimidine derivatives using microwave-assisted method

Some new compounds of 2-amino-4,6-diarylpyrimidines have been synthesized from corresponding substituted chalcones and guanidine hydrochloride using two different synthetic methods in microwave oven. The products formed were equally available and confirmed by IR, 1 H-NMR and mass spectral data. | Journal of Chemistry, Vol. 47 (5), P. 628 - 633, 2009 SYNTHESIS OF SOME 2-AMINO-4,6-DIARYLPYRIMIDINE DERIVATIVES USING MICROWAVE-ASSISTED METHOD Received 5 January 2009 1* Nguyen Dinh Thanh , Nguyen Thi Thanh Mai2, Nguyen Phuong Nhan1 1 Faculty of Chemistry, College of Science, VNU 2 National Institute of Forensic Medicine Abstract Some new compounds of 2-amino-4,6-diarylpyrimidines have been synthesized from corresponding substituted chalcones and guanidine hydrochloride using two different synthetic methods in microwave oven. The products formed were equally available and confirmed by IR, 1 H-NMR and mass spectral data. I - INTRODUCTION The microwave-assisted organic synthesis method is becoming an increasingly popular method of heating which replaces the classical ones because it proves to be a clean, cheap, and convenient method. This method often affords higher yields in short reaction times and has been extended to almost all areas of chemistry. Numerous organic reactions assisted by microwave heating have been performed and reviewed in articles or books [1]. These reactions involved different ones, such as the acylation and alkylation reaction, aromatic nucleophilic substitution, condensation, cycloaddictions, heterocyclization, rearrangements, reaction of organometallic compounds, oxidation and reduction. On another hand, pyrimidine derivatives occupy unique positions as leiodynamic agents, both as essential components of nucleic acids and also as therapeutic agents [2, 3]. In the previous paper, we reported on synthesis of several 2-amino-4,6diarylpyrimidines from guanidine hydrochloride and substituted chalcones using classical heating method [4, 5]. In the present study, 628 these amines have been synthesized using microwave-assisted method. II - EXPERIMENT Melting point of the synthesized compound was measured by using Thiele’s apparatus in capillary and uncorrected. The FTIR-spectra were recorded on Magna 760 FT-IR Spectrometer (NICOLET, USA) .