tailieunhanh - Anthraquinones from Hedyotis pinifolia

Hedyotis pinifolia Wall ex (Vietnamsese name An điền l th«ng), family of Rubiaceae, has not yet been chemically studied. From the aerial parts of H. pinifolia, four anthraquinones had been isolated: 1,6-dihydroxy-7-methoxy-2-methylanthraquinone (1), 1,6-dihydroxy-2- methylanthraquinone (2), 3,6-dihydroxy-2-methylanthraquinon (3) and 1,3,6-trihydroxy-2- methylanthraquinone (4). Their chemical structures were established by spectroscopic analysis. | Journal of Chemistry, Vol. 47 (5), P. 581 - 585, 2009 ANTHRAQUINONES FROM HEDYOTIS PINIFOLIA Received 19 Oct 2007 LE HOANG DUY1, NGUYEN KIM PHI PHUNG2 1 Pham Van Dong University, Quang Ngai Province 2 University of Natural Sciences, National University Ho Chi Minh City ABSTRACT Hedyotis pinifolia Wall ex (Vietnamsese name An điền l¸ th«ng), family of Rubiaceae, has not yet been chemically studied. From the aerial parts of H. pinifolia, four anthraquinones had been isolated: 1,6-dihydroxy-7-methoxy-2-methylanthraquinone (1), 1,6-dihydroxy-2methylanthraquinone (2), 3,6-dihydroxy-2-methylanthraquinon (3) and 1,3,6-trihydroxy-2methylanthraquinone (4). Their chemical structures were established by spectroscopic analysis. O H3C-O 7 6 HO 8 A 5 (1) 12 11 9 B 10 O OH 1 2 13 14 C 3 4 CH3 O 7 6 O 7 6 HO 8 A 5 (3) 12 11 9 B 10 1 2 13 14 C 3 4 CH3 HO 8 A 5 (2) OH 12 11 9 B 10 OH 1 2 13 14 C 3 4 CH3 7 6 O HO (4) O OH O 8 A 5 12 11 9 B 10 1 2 13 14 C 3 4 CH3 OH O Keywords: Rubiaceae, Hedyotis pinifolia, anthraquinone. I - INTRODUCTION Several species of Hedyotis genus (Rubiaceae) are used in traditional medicine in a number of Asian countries including Vietnam [1, 2]. There are approximately 180 species recorded of which 56 were identified in Vietnam [2, 3]. Hedyotis pinifolia Wall ex G. Don is a small herb (up to 25 cm tall) commonly found in sandy areas from Hue to the South of Vietnam2. Previous studies showed that the genus Hedyotis contained anthraquinones1-6, but there have been no anthraquinone compounds isolated from Hedyotis pinifolia. From the aerial parts of Hedyotis pinifolia, we isolated four anthraquinones (1-4). The structural elucidation of these compounds was reported. II - EXPERIMENTAL 1. General procedures Melting points were determined on a Maquene hot stage apparatus and were uncorrected. MS, 1H-, 13C-, DEPT- and 2DNMR, H-H COSY were recorded in The Institute of Chemistry, Vietnamese Academy of Science .