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Some chemical constituents isolated from acorus tatarinowii schott

A new 8,1 -neolignan, tatarinone, 4-[2-(1,2,3-trimethoxybenz-5-yl)-1-methylethyl]-2,5- dimethoxy-4-(2-propenyl)-2,5-cyclohexadien-1-one, has been isolated from Acorus tatarinowii rhizome and its structure determined by spectroscopic methods, including 2D-NMR spectra. Asarylaldehyde and a mixture of -asarone and -asarone were also isolated and indentified. | Journal of Chemistry Vol. 45 3 P. 356 - 362 2007 SOME CHEMICAL CONSTITUENTS ISOLATED FROM ACORUS TATARINOWII SCHOTT. Received 20 May 2005 NGUYEN THE DUNG1 NGUYEN THI HONG VAN1 PHAM DINH TY1 W. C. TAYLOR2 institute of Natural Products Chemistry VAST Vietnam 2School of Chemistry University of Sydney NSW 2006 Australia SUMMARY A new 8 1 -neolignan tatarinone 4- 2- 1 2 3-trimethoxybenz-5-yl -1-methylethyl -2 5-dimethoxy-4- 2-propenyl -2 5-cyclohexadien-1-one has been isolated from Acorus tatarinowii rhizome and its structure determined by spectroscopic methods including 2D-NMR spectra. Asarylaldehyde and a mixture of a-asarone and ft-asarone were also isolated and indentified. Keywords Acorus tatarinowii Araceae 8 1 -neolignans asarylaldehyde a-asarone P-asarone NMR. I - INTRODUCTION Acorus tatarinowii Schott Araceae grows wild on the banks of mountain streams in Vietnam Vietnamese name Thach xuong bo and is also found in China and India. The rhizomes are used as a herbal medicine with stomachic and sedative properties 1 . We have previously reported the isolation of 5-hydroxy-4-oxo-pentanoic acid from the rhizomes 2 and now report a new neolignan tatarinone 1. Together with 1 a two-isomer mixture of a-asarone 4 and P-asarone 5 asarylaldehyde 6 three known other compounds were also reported. II - EXPERIMENTAL The melting point was determined on an Electrothermal AI9200 instrument IR spectrum was recorded on an Impact-410-Nicolet instrument Institute of Chemistry - VAST Vietnam an EI-MS was recorded on a MS-Engine 5989B-HP instrument Institute of Chemistry - VAST Vietnam and EI-MS and HREI-mS were recorded on a Kratos MS25 RFA instrument School of Chemistry -356 University of Brisbane Australia unless otherwise stated 1D- and 2D-NMR spectra were recorded for CDCl3 solutions on a Bruker Avance 500 spectrometer Institute of Chemistry - VAST Vietnam and Bruker Avance 400 spectrometer School of Chemistry - University of Sydney Australia . The optical rotation on a CHCl3 .