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Báo cáo y học: " Disrupting the rhythm of depression: design and protocol of a randomized controlled trial on preventing relapse using brief cognitive therapy with or without antidepressants"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Disrupting the rhythm of depression: design and protocol of a randomized controlled trial on preventing relapse using brief cognitive therapy with or without antidepressants | Bockting et al. BMC Psychiatry 2011 11 8 http www.biomedcentral.eom 1471-244X 11 8 BMC Psychiatry STUDY PROTOCOL Open Access Disrupting the rhythm of depression design and protocol of a randomized controlled trial on preventing relapse using brief cognitive therapy with or without antidepressants 1 1.2 1 3 3 Claudi LH Bockting 1 Hermien J Elgersma 11 Gerard D van Rijsbergen Peter de Jonge Johan Ormel Prib R I cl oti c4 A Dpnn i c star ll 4 Pofor I Ho Imri d Pr nb PK II Poofcirc5 K Iar I C II I I 11 lihiorc6 A rnmirl Arnf76 Ell Busmens 1 A Dennis Dial It 1 Peiei J e Jong 1 Fien PML Peeieis 1 Iviaicus JH Huieis 1 Ainou aiiiiz 1 Peter Muris71 Willem A Nolen31 Aart H Schene81 Steven D Hollon9 Abstract Background Maintenance treatment with antidepressants is the leading strategy to prevent relapse and recurrence in patients with recurrent major depressive disorder MDD who have responded to acute treatment with antidepressants AD . However in clinical practice most patients up to 70-80 are not willing to take this medication after remission or take too low dosages. Moreover as patients need to take medication for several years1 it may not be the most cost-effective strategy. The best established effective and available alternative is brief cognitive therapy CT . However it is unclear whether brief CT while tapering antidepressants AD is an effective alternative for long term use of AD in recurrent depression. In addition1 it is unclear whether the combination of AD to brief CT is beneficial. Methods design Therefore1 we will compare the effectiveness and cost-effectiveness of brief CT while tapering AD to maintenance AD and the combination of CT with maintenance AD. In addition1 we examine whether the prophylactic effect of CT was due to CT tackling illness related risk factors for recurrence such as residual symptoms or to its efficacy to modify presumed vulnerability factors of recurrence e.g. rigid explicit and or implicit dysfunctional attitudes . This is a .