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Báo cáo y học: "Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders | Kao and Liu BMC Psychiatry 2010 10 63 http www.biomedcentral.com 1471-244X 10 63 BMC Psychiatry RESEARCH ARTICLE Open Access Effects of age of onset on clinical characteristics in schizophrenia spectrum disorders Yu-Chen Kao1 Yia-Ping Liu2 Abstract Background Over the last few decades research regarding the age of onset of schizophrenia and its relationship with other clinical variables has been incorporated into clinical practices. However reports of potential differences in demographic and clinical characteristics between early- and adult-onset schizophrenia spectrum disorders have been controversial. Thus this study aims to assess differences in demographic and clinical characteristics correlated with age of illness onset in schizophrenia spectrum disorders. Methods Data were collected from 104 patients with schizophrenia and schizoaffective disorder. Diagnosis was made via structured clinical interviews. Assessments of psychiatric symptoms and social and global functioning were completed. The effect of age of onset on demographic and clinical variables was examined using correlation analyses and binary logistic regression models. We chose 17 years of age as the cut-off for early-onset schizophrenia spectrum disorders based on a recent clinical consensus. We further investigated differences in the severity of psychopathology and other clinical variables between the early- and adult-onset groups. Results The binary logistic regression analysis showed that age of onset was significantly related to the cognitive component of the Positive and Negative Syndrome Scale PANSS odds ratio OR 0.58 95 confidence interval CI 0.872-0.985 p 0.001 and Barratt Impulsiveness Scale BIS score OR 0.94 95 CI 0.447-0.744 p 0.015 . Patients with early onset of schizophrenia spectrum disorders had significantly greater levels of cognitive impairment and higher impulsivity. There were significant differences between several demographic and clinical variables including the negative .