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Báo cáo y học: " A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis | Hardoy et al. BMC Psychiatry 2011 11 148 http www.biomedcentral.com 1471-244X 11 148 BMC Psychiatry RESEARCH ARTICLE Open Access A pattern of cerebral perfusion anomalies between Major Depressive Disorder and Hashimoto Thyroiditis 1 2 3 2 2 Maria Carolina Hardoy Mariangela Cadeddu Alessandra Serra Maria Francesca Moro Gioia Mura in K I - I I 11-. f s2 l Vi r h l l D p s 4-4 I rrrs ĩ I Fz-V A5 D I z I I r 13 h ỉ VI z D I z t 3 I h ỉ I irzt rd K f- 2 Gisa Mellino Krishna M Bhat Gianmarco Altoé Paolo Usai Mario Piga and Mauro G Carta Abstract Background This study aims to evaluate relationship between three different clinical conditions Major Depressive Disorders MDD Hashimoto Thyroiditis HT and reduction in regional Cerebral Blood Flow rCBF in order to explore the possibility that patients with HT and MDD have specific pattern s of cerebral perfusion. Methods Design Analysis of data derived from two separate data banks. Sample 54 subjects 32 with HT 29 women mean age 38.8 13.9 22 without HT 19 women mean age 36.5 12.25 . Assessment Psychiatric diagnosis was carried out by Simplified Composite International Diagnostic Interview CIDIS using DSM-IV categories cerebral perfusion was measured by 99 mTc-ECD SPECT. Statistical analysis was done through logistic regression. Results MDD appears to be associated with left frontal hypoperfusion left temporal hypoperfusion diffuse hypoperfusion and parietal perfusion asymmetry. A statistically significant association between parietal perfusion asymmetry and MDD was found only in the HT group. Conclusion In HT MDD is characterized by a parietal flow asymmetry. However the specificity of rCBF in MDD with HT should be confirmed in a control sample with consideration for other health conditions. Moreover this should be investigated with a longitudinally designed study in order to determine a possible pathogenic cause. Future studies with a much larger sample size should clarify whether a particular perfusion pattern is associated .