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Báo cáo khoa học: "Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome: results of a meta-analysis. | Available online http ccforum.eom content 10 2 R41 Research Exogenous pulmonary surfactant for the treatment of adult patients with acute respiratory distress syndrome results of a meta-analysis Warren J Davidson1 Del Dorscheid1 2 Roger Spragg3 Michael Schulzer1 Edwin Mak1 and Najib T Ayas1 2 4 Department of Medicine University of British Columbia Vancouver British Columbia Canada intensive Care Unit Providence Healthcare Vancouver British Columbia Canada 3University of California at San Diego California USA 4Centre for Clinical Epidemiology and Evaluation Vancouver Coastal Health Research Institute Vancouver British Columbia Canada Corresponding author Warren J Davidson Warren.Davidson@calgaryhealthregion.ca Received 2 Dec 2005 Revisions requested 23 Jan 2006 Revisions received 9 Feb 2006 Accepted 13 Feb 2006 Published 8 Mar 2006 Critical Care 2006 10 R41 doi 10.1186 cc4851 This article is online at http ccforum.com content 10 2 R41 2006 Davidson et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction The purpose of this study was to perform a systematic review and meta-analysis of exogenous surfactant administration to assess whether this therapy may be useful in adult patients with acute respiratory distress syndrome. Methods We performed a computerized literature search from 1966 to December 2005 to identify randomized clinical trials. The primary outcome measure was mortality 28-30 days after randomization. Secondary outcome measures included a change in oxygenation PaO2 FiO2 ratio the number of ventilation-free days and the mean duration of ventilation. Metaanalysis was performed using the inverse variance method. Results Two hundred and fifty-one articles were identified. Five studies