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Managing pregnancy in inflammatory rheumatological diseases

Collection of reports on medical research published in medical journals General Psychiatry provides medical knowledge about your topic: Managing pregnancy in inflammatory rheumatological diseases . | Jain and Gordon Arthritis Research Therapy 2011 13 206 http arthritis-research.eom content 13 1 206 REVIEW L_ Managing pregnancy in inflammatory rheumatological diseases Varsha Jain1 and Caroline Gordon 1 2 Abstract Historically pregnancy in women with many inflammatory rheumatic diseases was not considered safe and was discouraged. Combined care allows these pregnancies to be managed optimally with the majority of outcomes being favorable. Disease activity at the time of conception and anti-phospholipid antibodies are responsible for most complications. Disease flares pre-eclampsia and thrombosis are the main maternal complications whereas fetal loss and intrauterine growth restriction are the main fetal complications. Antirheumatic drugs used during pregnancy and lactation to control disease activity are corticosteroids hydroxychloroquine sulphasalzine and azathioprine. Vaginal delivery is possible in most circumstances with cesarean section being reserved for complications. Introduction Autoimmune rheumatic disease covers a spectrum of conditions including systemic lupus erythematosus SLE antiphospholipid syndrome APS rheumatoid arthritis RA other inflammatory arthropathies spondyloarthro-pathies systemic sclerosis SSc and systemic vascu-litides. Historically pregnancy was not deemed safe in women with multisystem rheumatic diseases either because of the risk of that their condition would deteriorate or because of their medications. As this review will show this view has changed and current opinion is that with good disease control careful planning and combined management delivery of healthy babies is often possible. Family size is smaller in women with rheumatic diseases because of a combination of factors including Correspondence p.c.gordon@bham.ac.uk 2Rheumatology Research Group School of Immunity and Infection College of Medical and Dental Sciences University of Birmingham Vincent Drive Birmingham UK Full list of author information is available at the