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Báo cáo y học: " Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis. | Respiratory Research BioMed Central Research Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis Brian D Gelbman1 Adriana Heguy 2 Timothy P O Connor 2 Joseph Zabner3 and Ronald G Crystal 1 2 Open Access Address division of Pulmonary and Critical Care Medicine Weill Medical College of Cornell University New York New York USA 2Department of Genetic Medicine Weill Medical College of Cornell University New York New York USA and 3Pulmonary Critical Care and Occupational Medicine Department of Internal Medicine University of Iowa Iowa City IA USA Email Brian D Gelbman - geneticmedicine@med.cornell.edu Adriana Heguy - geneticmedicine@med.cornell.edu Timothy P O Connor - geneticmedicine@med.cornell.edu Joseph Zabner - geneticmedicine@med.cornell.edu Ronald G Crystal - geneticmedicine@med.cornell.edu Corresponding authors Published 8 February 2007 Respiratory Research 2007 8 10 doi l0.ll86 l465-992l-8-l0 Received 9 May 2006 Accepted 8 February 2007 This article is available from http respiratory-research.cOm content 8 l l0 2007 Gelbman et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cigarette smoke disrupts the protective barrier established by the airway epithelium through direct damage to the epithelial cells leading to cell death. Since the morphology of the airway epithelium of smokers does not typically demonstrate necrosis the most likely mechanism for epithelial cell death in response to cigarette smoke is apoptosis. We hypothesized that cigarette smoke directly up-regulates expression of apoptotic genes which could play a role in airway epithelial .