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Báo cáo y học: " Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. | Respiratory Research BioMed Central Research Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation Lena Uller 1 Jesper Mosolff Mathiesen2 Lisa Alenmyr3 Magnus Korsgren3 Trond Ulven2 Thomas Hogberg2 Gunnar Andersson2 Carl GA Persson3 and Evi Kostenis2 Open Access Address 1Dept. Experimental Medical Science Lund University Sweden 27TM Pharma A S Fremtidsvej 3 2970 Horsholm Denmark and 3Dept. Clinical Pharmacology Lund University Hospital Lund Sweden Email Lena Uller - lena.Uller@med.lu.se Jesper Mosolff Mathiesen - JMM@zp.dk Lisa Alenmyr - lisa.alenmyr@med.lu.se Magnus Korsgren - magnus.korsgren@med.lu.se Trond Ulven - ulven@chem.sdu.dk Thomas Hogberg - TH@7tm.com Gunnar Andersson - ga@7tm.com Carl GA Persson - carl.persson@med.lu.se Evi Kostenis - kostenis@uni-bonn.de Corresponding author Published 28 February 2007 Received 10 October 2006 Respiratory Research 2007 8 16 doi l0.ll86 l465-992l-8-l6 Accepted 28 February 2007 This article is available from http respiratory-research.cOm content 8 l l6 2007 Uller et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Mast cell-derived prostaglandin D2 PGD2 may contribute to eosinophilic inflammation and mucus production in allergic asthma. Chemoattractant receptor homologous molecule expressed on TH2 cells CRTH2 a high affinity receptor for prostaglandin D2 mediates trafficking of TH2-cells mast cells and eosinophils to inflammatory sites and has recently attracted interest as target for treatment of allergic airway diseases. The present study involving mice explores the specificity of CRTH2 antagonism of TM30089 .