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Báo cáo y học: "Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study. | Franklin et al. Arthritis Research Therapy 2010 12 R102 http arthritis-research.eom content 12 3 R102 RESEARCH ARTICLE Open Access Association between occupation and knee and hip replacement due to osteoarthritis a case-control study Jonas Franklin 1 2 Thorvaldur Ingvarsson1 3 4 Martin Englund2 5 and Stefan Lohmander2 Abstract Introduction The objective of this study was to examine the association between occupation and osteoarthritis OA leading to total knee TKR or hip THR joint replacement. Methods The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of 2002 were invited to participate. First degree relatives of participating patients served as controls. N 1 408 cases 832 women and n 1 082 controls 592 women 60 years or older and who had adequately answered a questionnaire were analyzed. Occupations were classified according to international standards. Inheritance of occupations was calculated by using the Icelandic Genealogy Database. Results The age adjusted odds ratio OR for male farmers getting a TKR due to OA was 5.1 95 confidence interval CI 2.1 to 12.4 and for a male farmer getting a THR due to OA the OR was 3.6 95 CI 2.1 to 6.2 . The OR for a fisherman getting a TKR was 3.3 95 CI 1.3 to 8.4 . No other occupations showed increased risk for men. For women there was no increased risk for any occupation. Farming and fishing were also the occupations that showed the greatest degree of inheritance. Conclusions These results support an association in males between occupations with heavy physical load and both TKR and THR for OA. Introduction There are several possible risk factors for osteoarthritis OA of the knee and hip. Body mass index BMI is well established as a risk factor for both hip and knee OA for both genders 1 2 . It has been shown that high BMI precedes knee OA and thus causality can be assumed 3 4 . Occupation is another risk factor that has been linked to OA. Studies