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Báo cáo y học: "Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis. | Guler-Yuksel et al. Arthritis Research Therapy 2010 12 R96 http arthritis-research.eom content 12 3 R96 RESEARCH ARTICLE Open Access Accelerated hand bone mineral density loss is associated with progressive joint damage in hands and feet in recent-onset rheumatoid arthritis MelekGuler-Yuksel 1 Naomi B Klarenbeek1 Yvonne PM Goekoop-Ruiterman1 Jeska Kde Vries-Bouwstra2 Sjoerd M van der Kooij1 Andreas H Gerards3 H Karel Ronday4 Tom WJ Huizinga1 Ben AC Dijkmans2 5 Cornelia F Allaart1 and Willem F Lems2 5 Abstract Introduction To investigate whether accelerated hand bone mineral density BMD loss is associated with progressive joint damage in hands and feet in the first year of rheumatoid arthritis RA and whether it is an independent predictor of subsequent progressive total joint damage after 4 years. Methods In 256 recent-onset RA patients baseline and 1-year hand BMD was measured in metacarpals 2-4 by digital X-ray radiogrammetry. Joint damage in hands and feet were scored in random order according to the Sharp-van der Heijde method at baseline and yearly up to 4 years. Results 68 of the patients had accelerated hand BMD loss -0.003 g cm2 in the first year of RA. Hand BMD loss was associated with progressive joint damage after 1 year both in hands and feet with odds ratios OR 95 confidence intervals CI of 5.3 1.3-20.9 and 3.1 1.0-9.7 . In univariate analysis hand BMD loss in the first year was a predictor of subsequent progressive total joint damage after 4 years with an OR 95 CI of 3.1 1.3-7.6 . Multivariate analysis showed that only progressive joint damage in the first year and anti-citrullinated protein antibody positivity were independent predictors of long-term progressive joint damage. Conclusions In the first year of RA accelerated hand BMD loss is associated with progressive joint damage in both hands and feet. Hand BMD loss in the first year of recent-onset RA predicts subsequent progressive total joint damage however not independent of progressive joint .