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Báo cáo y học: " Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Localized 1H-NMR spectroscopy in patients with fibromyalgia: a controlled study of changes in cerebral glutamate/glutamine, inositol, choline, and N-acetylaspartate. | Fayed et al. Arthritis Research Therapy 2010 12 R134 http arthritis-research.eom content 12 4 R134 RESEARCH ARTICLE Open Access Localized 1H-NMR spectroscopy in patients with fibromyalgia a controlled study of changes in cerebral glutamate glutamine inositol choline and W-acetylaspartate Nicolas Fayed1 Javier Garcia-Campayo 2 3 Rosa Magallon3 4 Helena Andrés-Bergareche2 Juan V Luciano3 5 Eva Andres6 and Julián Beltran1 Abstract Introduction The purpose of this study was to investigate whether single-voxel SV proton magnetic resonance spectroscopy MRS diffusion-weighted imaging DWI and diffusion tensor imaging DTI detected differences between fibromyalgia FM patients and healthy controls. We also searched for correlations between neuroimaging abnormalities and neuropsychological variables. Methods Ten patients with FM and 10 gender- and age-matched control subjects were studied. A neuropsychological examination DWI DTI and proton MRS were performed on the brain areas known to be associated with pain processing. Results Compared with healthy controls FM patients had significantly higher levels of glutamate glutamine Glx mean SD 10.71 0.50 arbitrary institutional units versus 9.89 1.04 P 0.049 and higher glutamate glutamine creatine Glx Cr ratios 1.90 0.12 versus 1.72 0.23 P 0.034 in the posterior gyrus. Myoinositol Ins levels of the right and left hippocampi were significantly lower in FM patients 4.49 0.74 versus 5.17 0.62 P 0.008 and 4.91 0.85 versus 6.09 0.78 P 0.004 respectively . In FM patients decreased myoinositol creatine Ins Cr ratios were found in the left sensorimotor area P 0.05 and the left hippocampus P 0.002 and lower levels of choline P 0.019 and N-acetyl aspartate N-acetyl aspartyl glutamate NAA NAG P 0.034 in the left hippocampus. Significant correlations between depression pain and global function and the posterior gyrus Glx levels and Glx Cr ratios were observed. Conclusions Glx within the posterior gyrus could be a pathologic factor in FM. .