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Báo cáo y học: "Gait changes precede overt arthritis and strongly correlate with symptoms and histopathological events in pristane-induced arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Gait changes precede overt arthritis and strongly correlate with symptoms and histopathological events in pristane-induced arthritis. | Hoffmann et al. Arthritis Research Therapy 2010 12 R41 http arthritis-research.eom content 12 2 R41 RESEARCH ARTICLE Open Access Gait changes precede overt arthritis and strongly correlate with symptoms and histopathological events in pristane-induced arthritis Markus H Hoffmann 1 Rudolf Hopf2 Birgit Niederreiter1 Heinz Redl2 Josef S Smolen1 Gunter Steiner1 Abstract Introduction Pristane-induced arthritis PIA in the rat has been described as an animal model of inflammatory arthritis which exhibits features similar to rheumatoid arthritis in humans such as a chronic destructive and symmetrical involvement of peripheral joints. However so far little is known about the earliest inflammatory events and their influence on locomotor behaviour during the course of PIA. To investigate this issue a detailed analysis of the pathologic changes occurring during the prodromal and early stages of PIA was performed. Methods Arthritis was induced in DA.rats by injection of 150 pl 2 6 10 4-tetramethyl-pentadecane pristane at the base of the tail and changes in locomotor behaviour of the affected paws were monitored using the CatWalk quantitative gait analysis system. The pathologic events occurring in the joints of pristane-injected animals were studied before onset at onset and during acute phase of arthritis by histological methods. Results Gait analysis revealed that changes in locomotion such as reduced paw print areas and stance phase time are already apparent before the onset of clinically discernible arthritis symptoms erythema paw swelling and correlate with PIA scores. In agreement with these findings inflammatory tenosynovitis could be observed by histology already before the onset of erythema and swelling of the respective paws. In the most heavily affected rats also irregularities in step sequence patterns occurred A kinetic analysis of clinical and histological findings demonstrated that gait changes precede the pathological changes occurring during the acute phase of