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Báo cáo y học: " Multi-symptom asthma is closely related to nasal blockage, rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Multi-symptom asthma is closely related to nasal blockage, rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study. | Lõtvall et al. Respiratory Research 2010 11 163 http respiratory-research.eom content 11 1 163 RESPIRATORY RESEARCH RESEARCH Open Access Multi-symptom asthma is closely related to nasal blockage rhinorrhea and symptoms of chronic rhinosinusitis-evidence from the West Sweden Asthma Study Jan Lotvall Linda Ekerljung Bo Lundback Abstract Background We have previously shown that approximately 25 of those with asthma in West Sweden have multiple asthma symptoms which may describe a group of patients with more severe disease. Furthermore asthma is associated with several co-morbid diseases including rhinitis and chronic rhinosinusitis. The aim of this study was to determine whether multi-symptom asthma is related to signs of severe asthma and to investigate the association between multi-symptom asthma and different symptoms of allergic and chronic rhinosinusitis. Methods This study analyzed data on asthma symptoms rhinitis and chronic rhinosinusitis from the 2008 West Sweden Asthma Study which is an epidemiologically based study using the OLIN and GA2LEN respiratory and allergy focused questionnaires. Results Multi-symptom asthma was present in 2.1 of the general population. Subjects with multi-symptom asthma had more than double the risk of having night-time awakenings caused by asthma compared with those with fewer asthma symptoms P 0.001 . The prevalence of allergic rhinitis was similar in the fewer- and multisymptom asthma groups but nasal blockage and rhinorrhea were significantly increased in those with multi-versus fewer-symptom asthma odds ratio 2.21 95 confidence interval 1.64-2.97 versus 1.49 1.10-2.02 respectively . Having any or one to four symptoms of chronic rhinosinusitis significantly increased the risk of having multi- versus fewer-symptom asthma P 0.01 . Conclusion An epidemiologically identified group of individuals with multiple asthma symptoms harbour to greater extent those with signs of severe asthma. The degree of rhinitis described by the .