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Báo cáo y học: " Systemic inflammation in chronic obstructive pulmonary disease: a population-based study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Systemic inflammation in chronic obstructive pulmonary disease: a population-based study. | Garcia-Rio et al. Respiratory Research 2010 11 63 http respiratory-research.eom content 11 1 63 RESPIRATORY RESEARCH RESEARCH Open Access Systemic inflammation in chronic obstructive pulmonary disease a population-based study Francisco Garcia-Rio 1 Marc Miravitlles2 Joan B Soriano3 Luis Munoz4 Enric Duran-Tauleria5 Guadalupe Sanchez6 Victor Sobradillo7 Julio Ancochea8 and EPI-SCAN Steering Committee Abstract Background Elevated circulating levels of several inflammatory biomarkers have been described in selected patient populations with COPD although less is known about their population-based distribution. The aims of this study were to compare the levels of several systemic biomarkers between stable COPD patients and healthy subjects from a population-based sample and to assess their distribution according to clinical variables. Methods This is a cross-sectional study design of participants in the EPI-SCAN study 40-80 years of age . Subjects with any other condition associated with an inflammatory process were excluded. COPD was defined as a postbronchodilator FEV1 FVC 0.70. The reference group was made of non-COPD subjects without respiratory symptoms associated diseases or prescription of medication. Subjects were evaluated with quality-of-life questionnaires spirometry and 6-minute walk tests. Serum C-reactive protein CRP tumor necrosis factor TNF -a interleukins IL-6 and IL-8 alphal-antitrypsin fibrinogen albumin and nitrites nitrates NOx were measured. Results We compared 324 COPD patients and 110 reference subjects. After adjusting for gender age BMI and tobacco consumption COPD patients showed higher levels of CRP 0.477 0.023 vs. 0.376 0.041 log mg L p 0.049 TNF-a 13.12 0.59 vs. 10.47 1.06 pg mL p 0.033 IL-8 7.56 0.63 vs. 3.57 1.13 pg ml p 0.033 and NOx 1.42 0.01 vs. 1.36 0.02 log nmol l p 0.048 than controls. In COPD patients serum concentrations of some biomarkers were related to severity and their exercise tolerance was related to serum concentrations of