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báo cáo hóa học: " Validation of the japanese version of the sarcoidosis health questionnaire: A cross-sectional study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Validation of the japanese version of the sarcoidosis health questionnaire: A cross-sectional study | Tanizawa et al. Health and Quality of Life Outcomes 2011 9 34 http www.hqlo.eom content 9 1 34 HEALTH AND QUALITY OF LIFE OUTCOMES SHORT REPORT Open Access Validation of the Japanese version of the sarcoidosis health questionnaire A cross-sectional study 1 1.2 3 T- 4 5 1 Kiminobu Tanizawa Tomohiro Handa 1 Sonoko Nagai Toru Oga Takeshi Kubo Yutaka Ito Kizuku Watanabe1 Kensaku Aihara1 Kazuo Chin4 Michiaki Mishima1 and Takateru Izumi3 Abstract Background Although impaired health-related quality of life HRQOL has been reported in patients with sarcoidosis there is currently no sarcoidosis-specific questionnaire in Japan. The 29-item Sarcoidosis Health Questionnaire SHQ originally developed in the United States is the only sarcoidosis-specific HRQOL questionnaire currently available. The primary aim of this study was to develop and validate a Japanese version of the SHQ. Findings The SHQ was translated into Japanese following the forward-backward procedure. The reliability and validity of the Japanese version of the SHQ were examined. One hundred twenty-two Japanese patients with biopsy-proven sarcoidosis were evaluated by the SHQ the Medical Outcomes Study 36-item short form SF-36 the St. George s Respiratory Questionnaire SGRQ chest radiography an electrocardiogram laboratory blood tests pulmonary function tests an echocardiogram and assessments of dyspnea and depressive symptoms. The SHQ was found to have acceptable levels of internal consistency Cronbach s coefficient a values 0.68 to 0.91 . SHQ scores correlated significantly with scores on the SF-36 and SGRQ. The domain or total scores on the SHQ also significantly correlated with serum levels of the soluble interleukin-2 receptor the percentage of the predicted forced vital capacity pulmonary arterial systolic pressure dyspnea and depressive symptoms. Also the SHQ scores of patients who had one or two organ systems affected by sarcoidosis were significantly different from those of patients who had three or more .