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Báo cáo khoa học: "The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques. | Vranova et al. Radiation Oncology 2011 6 87 http www.ro-journal.eom content 6 1 87 RADIATION ONCOLOGY RESEARCH Open Access The evolution of rectal and urinary toxicity and immune response in prostate cancer patients treated with two three-dimensional conformal radiotherapy techniques lana l rsìr-iaxa 1 4 t in lzi r.1 I2 bn Pirhtor3 Mirndaw Ctarcac1 Piccaraxa ancl n7ũf Cacii 7 .i4 1 Jal Id vrdnovd Stepdn Vllldkuidu Jdn Richter IVIIIUsldv Stdrec nlllld riseiovd dl Id Jozef Rosind Abstract Background Our resedrch compdred whole pelvic WP dnd prostdte-only PO 3-dlmenslondl conformdl radiotherapy 3DCRT techniques in terms of the incidence dnd evolution of dcute dnd ldte toxicity of the rectum dnd urindry blddder dnd identified the PTV-pdrdmeters influencing these ddmdges dnd chdnges in dntitumor immune response. Methods We dndlyzed 197 prostdte cdncer pdtients undergoing 3DCRT for gdstrointestindl GI dnd genitourindry GU toxicities dnd conducted d pilot immunologicdl study including flow cytometry dnd dn NK cell cytotoxicity dssdy. Acute dnd ldte toxicities were recorded dccording to the RTOG dnd the LENT-SOMA scdles respectively. Univdridte dnd multivdridte dndlyses were conducted for fdctors dssocidted with toxicity. Results In the WP group dn incredse of dcute rectdl toxicity wds observed. A higher incidence of ldte GI GU toxicity dppedred in the PO group. Only 18 pdtients WP-7.76 dnd PO-11.11 suffered severe ldte GI toxicity dnd 26 pdtients WP-11.21 dnd PO-16.05 severe ldte GU toxicity. In the mdjority of dcute toxicity suffering pdtients the diminution of ldte GI GU toxicity to grade 1 or to no toxicity dfter radiotherapy wds observed. The 3DCRT technique itself pdtient dge T stdge of TNM cldssificdtion surgicdl intervention dnd some dose-volume pdrdmeters emerged ds importdnt fdctors in the probdbility of developing dcute dnd ldte GI GU toxicity. The proportion dnd differentidtion of NK cells positively correldted during 3DCRT dnd negdtively so dfter its .