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Báo cáo khoa học: "Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy. | Hu etal. Radiation Oncology 2010 5 29 http www.ro-journal.eom content 5 1 29 RADIATION ONCOLOGY RESEARCH Open Access Use of kilovoltage X-ray volume imaging in patient dose calculation for head-and-neck and partial brain radiation therapy Weigang Hu 1 Jinsong Ye2 Jiazhou Wang1 Xuejun Ma1 and Zhen Zhang 1 Abstract Background To evaluate the accuracy of using kilovoltage x-ray cone-beam computed tomography kV-CBCT imaging for in vivo dose calculations. Methods A Region-of-Interest ROI CT number mapping method was developed to generate the cone-beam CT number vs. relative electron density calibration curve for 3D dose calculations. The stability of the results was validated for three consecutive months. The method was evaluated on three brain tumors and three head-and-neck tumor cases. For each patient kV-CBCT images were acquired on the first treatment day and two-week intervals on the Elekta XVI system. The delivered dose distributions were calculated by applying the patients treatment plans to the kV-CBCT images. The resulting dose distributions and dose volume histograms DVHs of the tumor and critical structures were compared to the original treatment plan. Results The kV-CBCT electron density calibration was stable within 1.5 over a three-month period. The DVH and dose distribution comparison based on the planning CT and the initial kV-CBCT showed good agreements for majority of cases. The doses calculated from the planning CT and kV-CBCT were compared on planes perpendicular to the beam axes and passing through the isocenter. Using Y analysis with a criterion of 2 mm 2 and a threshold of 10 more than 99.5 of the points on the iso-planes exhibited Y 1. For one patient kV-CBCT images detected 5.8 dose variation in the right parotid due to tumor shrinkage and patient weight loss. Conclusions ROI mapping method is an effective method for the creation of kV-CBCT electron density calibration curves for head-and-neck and brain tumor patients. Dose variations as .