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Báo cáo khoa học: "Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy. | Shim etal. Radiation Oncology 2010 5 43 http www.ro-journal.eom content 5 1 43 RADIATION ONCOLOGY RESEARCH Open Access Clinical outcomes for T1-2N0-1 oral tongue cancer patients underwent surgery with and without postoperative radiotherapy Su Jung Shim1 Jihye Cha2 Woong Sub Koom2 Gwi Eon Kim2 Chang Geol Lee2 Eun Chang Choi3 and Ki Chang Keum 2 Abstract Background The aim of this study was to assess the results of curative surgery with and without radiotherapy in patients with T1-2N0-1 oral tongue squamous cell carcinoma OSCC and to evaluate survival and prognostic factors. Methods Retrospective analysis of 86 patients with T1-2N0-1 OSCC who received surgery between January 2000 and December 2006. Fourteen patients 16.3 received postoperative radiotherapy PORT . Patient characteristics tumor characteristics treatment modality failure patterns and survival rates were analyzed. Results The median follow-up was 45 months. The five-year overall survival OS and disease-free survival DFS rates were 80.8 and 80.2 respectively. Higher tumor grade and invasion depth 0.5 cm were the significant prognostic factors affecting five-year OS and DFS OS rate 65 vs. 91 p 0.001 for grade 66 vs. 92 p 0.01 for invasion depth DFS rate 69 vs. 88 p 0.005 for grade 66 vs. 92 p 0.013 for invasion depth . In the risk group there was no local failure in patients with postoperative radiotherapy. Conclusions In T1-2N0-1 OSCC factors that affected prognosis after primary surgery were higher tumor grade and deep invasion depth over 0.5 cm. Postoperative radiotherapy should be considered in early oral tongue cancer patients with these high-risk pathologic features. Background The oral tongue is the most common subsite for squamous cell carcinoma of the oral cavity excluding the lip 1 . In advanced cases surgical resection followed by radiotherapy RT with or without chemotherapy is performed and it seems to be beneficial. In early cases T1-2 surgery is often the preferred form of treatment 2 . .