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Báo cáo y học: "HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis. | Available online http arthritis-research.eom content 8 6 R185 Research article HLA-C locus alleles may modulate the clinical expression of psoriatic arthritis Ruben Queiro1 Segundo Gonzalez2 Carlos Lopez-Larrea3 Mercedes Alperi1 Cristina Sarasqueta4 Jose Luis Riestra1 and Javier Ballina1 Rheumatology Service Hospital Universitario Central de Asturias HUCA C Celestino Villamil s n. 33006 Oviedo Spain 2Department of Functional Biology University of Oviedo C Julian Claveria s n. 33006 Oviedo Spain 3Immunology Department Hospital Universitario Central de Asturias HUCA C Celestino Villamil s n. 33006 Oviedo Spain 4Clinical Epidemiology Unit Complejo Hospitalario Donostia P del Dr Beguiristain 111 20014 San Sebastian Basque Country Spain Corresponding author Ruben Queiro ruquei@mixmail.com Received 15 Aug 2006 Revisions requested 4 Sep 2006 Revisions received 4 Nov 2006 Accepted 13 Dec 2006 Published 13 Dec 2006 Arthritis Research Therapy 2006 8 R185 doi 10.1186 ar2097 This article is online at http arthritis-research.com content 8 6 R185 2006 Queiro et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract The aim of the present study was to evaluate the relative contribution of human leukocyte antigen HLA -C locus alleles in determining the risk and the clinical expression of psoriatic arthritis PsA . One hundred PsA patients were randomly selected and grouped into three disease subsets oligoarthritis n 40 polyarthritis n 25 and spondylitis n 35 . The HLA-C locus profile of this cohort was studied by methods based on molecular biology and was compared with that of 45 patients with psoriasis vulgaris and 177 healthy blood donors from the same ethnic origin. HLA-Cw 0602 was found associated with both psoriasis .