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Báo cáo y học: "Alteration of serotonin transporter density and activity in fibromyalgia"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Alteration of serotonin transporter density and activity in fibromyalgia. | Available online http arthritis-research.eom content 8 4 R99 Research article Alteration of serotonin transporter density and activity in fibromyalgia Laura Bazzichi1 Gino Giannaccini2 Laura Betti2 Giovanni Mascia2 Laura Fabbrini2 Paola Italiani2 Francesca De Feo2 Tiziana Giuliano1 Camillo Giacomelli2 Alessandra Rossi2 Antonio Lucacchini2 and Stefano Bombardieri1 Open Access Department of Internal Medicine Division of Rheumatology University of Pisa Via Roma 67 - 56126 PISA Italy department of Psychiatry Neurobiology Pharmacology and Biotechnology University of Pisa Via Bonanno 6 56126 Pisa Italy Corresponding author Antonio Lucacchini lucas@farm.unipi.it Received 21 Feb 2006 Revisions requested 30 Mar 2006 Revisions received 12 May 2006 Accepted 31 May 2006 Published 21 Jun 2006 Arthritis Research Therapy 2006 8 R99 doi 10.1186 ar1982 This article is online at http arthritis-research.com content 8 4 R99 2006 Bazzichi et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract The aim of the study was to evaluate the kinetic parameters of a specific serotonin transporter SERT and serotonin uptake in a mentally healthy subset of patients with fibromyalgia. Platelets were obtained from 40 patients and 38 healthy controls. SERT expression and functionality were evaluated through the measurement of 3H paroxetine binding and the 3H serotonin uptake itself. The values of maximal membrane binding capacity Bmax were statistically lower in the patients than in the healthy volunteers whereas the dissociation constant Kd did not show any statistically significant variations. Moreover a decrease in the maximal uptake rate of SERT max was demonstrated in the platelets of patients whereas the Michaelis constant Km did not show any .