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Báo cáo y học: " Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis. | Available online http arthritis-research.eom content 7 5 R1034 Research article Protective effect of vasoactive intestinal peptide on bone destruction in the collagen-induced arthritis model of rheumatoid arthritis Yasmina Juarranz1 Catalina Abad1 Carmen Martinez2 Alicia Arranz1 Irene Gutierrez-Canas3 Florencia Rosignoli1 Rosa P Gomariz1 and Javier Leceta1 Open Access 1Departamento Biología Celular Facultad de Biología Universidad Complutense de Madrid Madrid Spain 2Departamento Biología Celular Facultad de Medicina Universidad Complutense de Madrid Madrid Spain 3Servicio de Reumatología y Unidad de Investigación Hospital 12 de Octubre Madrid Spain Corresponding author Yasmina Juarranz yashina@bio.ucm.es Received 6 Apr 2005 Revisions requested 6 May 2005 Revisions received 17 May 2005 Accepted 2 Jun 2005 Published 23 Jun 2005 Arthritis Research Therapy 2005 7 R1034-R1045 DOI 10.1186 ar1779 This article is online at http arthritis-research.com content 7 5 R1034 2005 Juarranz et al. licensee BioMed Central Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Rheumatoid arthritis RA is an autoimmune disease of unknown etiology characterized by the presence of inflammatory synovitis accompanied by destruction of joint cartilage and bone. Treatment with vasoactive intestinal peptide VIP prevents experimental arthritis in animal models by downregulation of both autoimmune and inflammatory components of the disease. The aim of this study was to characterize the protective effect of VIP on bone erosion in collagen-induced arthritis CIA in mice. We have studied the expression of different mediators implicated in bone homeostasis such as inducible nitric oxide synthase iNOS cyclooxygenase-2 COX-2 receptor activator of nuclear factor-KB RANK receptor .