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Báo cáo khoa học: "Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Malignant mixed Mullerian tumors of the uterus: histopathological evaluation of cell cycle and apoptotic regulatory proteins | Kanthan et al. World Journal of Surgical Oncology 2010 8 60 http www.wjso.eom content 8 1 60 RESEARCH WORLD JOURNAL OF SURGICAL ONCOLOGY Open Access Malignant mixed Mullerian tumors of the uterus histopathological evaluation of cell cycle and apoptotic regulatory proteins Rani Kanthan Jenna-Lynn B Senger and Dana Diudea Abstract Aim The aim of our study was to evaluate survival outcomes in malignant mixed Mullerian tumors MMMT of the uterus with respect to the role of cell cycle and apoptotic regulatory proteins in the carcinomatous and sarcomatous components. Methods 23 cases of uterine MMMT identified from the Saskatchewan Cancer Agency 1970-1999 were evaluated. Immunohistochemical expression of Bad Mcl-1 bcl-x bak mdm2 bax p16 p21 p53 p27 EMA Bcl-2 Ki67 and PCNA was correlated with clinico-pathological data including survival outcomes. Results Histopathological examination confirmed malignant epithelial component with homologous 12 cases and heterologous 11 cases sarcomatous elements. P53 was strongly expressed 70-95 in 15 cases and negative in 5 cases. The average survival in the p53 ve cases was 3.56 years as opposed to 8.94 years in p53-ve cases. Overexpression of p16 and Mcl-1 were observed in patients with longer survival outcomes 2 years . P16 and p21 were overexpressed in the carcinomatous and sarcomatous elements respectively. Cyclin-D1 was focally expressed only in the carcinomatous elements. Conclusions Our study supports that a cell cycle and apoptotic regulatory protein dysregulation is an important pathway for tumorigenesis and b p53 is an important immunoprognostic marker in MMMT of the uterus. Background Malignant mixed Mullerian tumors MMMT of the uterus are rare high-grade neoplasms comprising only 12 of uterine cancers 1 and 3-5 of all uterine malignancies 2 . They are the most common variety of mixed epithelial and non-epithelial endometrial tumors with a clinically aggressive course 3 4 . Stage of the disease and the depth of myometrial .