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Báo cáo y học: "Effectiveness of injectable risperidone long-acting therapy for schizophrenia: data from the US, Spain, Australia, and Belgium"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effectiveness of injectable risperidone long-acting therapy for schizophrenia: data from the US, Spain, Australia, and Belgium. | Lambert et al. Annals of General Psychiatry 2011 10 10 http www.annals-general-psychiatry.eom content 10 1 10 ANNALS OF GENERAL PSYCHIATRY PRIMARY RESEARCH Open Access Effectiveness of injectable risperidone long-acting therapy for schizophrenia data from the US Spain Australia and Belgium Tim I mHorf 1 t IncA l l CMi 7ỉroc2t InconH Doi Iclronc3t TFioril fì rSoCm ITTỈ4 Thric K i kA7m25 D frir L C if f on6t IIIII Ldmbeit Josc M Olivdies Joseph I reuskens Ciieiilyn Ucjuuzd Ciiiis M ixuziiid Patrick Otten f nnrof f 71 ri or27 t An hmhc8 A 2 no K AnTuHHan9 I tan l i2n10t Qtanhcin c Podrini IQ77 Di-A Piirsini7t nrl Concetta Ciiveia An Jacobs Wayne iVidLiduueii Lian Mdu Stepien C nodiiguez Ridd Diiani and Kasem S Akhrasm Abstract Background Because wide variations in mental health care utilization exist throughout the world determining long-term effectiveness of psychotropic medications in a real-world setting would be beneficial to physicians and patients. The purpose of this analysis was to describe the effectiveness of injectable risperidone long-acting therapy RLAT for schizophrenia across countries. Methods This was a pragmatic analysis of data from two prospective observational studies conducted in the US Schizophrenia Outcomes Utilization Relapse and Clinical Evaluation SOURCE ClinicalTrials.gov registration number for the SOURCE study NCT00246194 and Spain Australia and Belgium electronic Schizophrenia Treatment Adherence Registry eSTAR . Two separate analyses were performed to assess clinical improvement during the study and estimate psychiatric hospitalization rates before and after RLAT initiation. Clinical improvement was evaluated using the Clinical Global Impressions-Severity CGI-S and Global Assessment of Functioning GAF scales and change from baseline was evaluated using paired t tests. Psychiatric hospitalization rates were analyzed using incidence densities and the bootstrap resampling method was used to examine differences between the prebaseline and .