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Báo cáo y học: "Intravenous immunoglobulin treatment of four patients with juvenile polyarticular arthritis associated with persistent parvovirus B19 infection and antiphospholipid antibodies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Intravenous immunoglobulin treatment of four patients with juvenile polyarticular arthritis associated with persistent parvovirus B19 infection and antiphospholipid antibodies. | Available online http arthritis-research.eom content 6 1 R1 Research article Open Access Intravenous immunoglobulin treatment of four patients with juvenile polyarticular arthritis associated with persistent parvovirus B19 infection and antiphospholipid antibodies Hartwig W Lehmann1 Annelie Plentz2 Philipp von Landenberg3 Esther Muller-Godeffroy4 and Susanne Modrow2 1 Rheumaklinik Bad Bramstedt Bad Bramstedt Germany institute for Medical Microbiology Universitat Regensburg Regensburg Germany 3Department for Clinical Chemistry and Laboratory Medicine Universitat Mainz Mainz Germany 4Clinic of Pediatrics Medizinische Universitat Lubeck Lubeck Germany Correspondence Susanne Modrow e-mail susanne.modrow@klinik.uni-regensburg.de Received 12 Jun 2003 Revisions requested 26 Aug 2003 Revisions received 29 Aug 2003 Accepted 24 Sep 2003 Published 10 Oct 2003 Arthritis Res Ther 2004 6 R1-R6 DOI 10.1186 ar1011 2004 Lehmann et al. licensee BioMed Central Ltd Print ISSN 1478-6354 Online ISSN 1478-6362 . This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Abstract Children with rheumatic oligoarthritis and polyarthritis frequently establish persistent parvovirus B19 infections that may be associated with the production of antiphospholipid antibodies anti-PL IgG . In this study we analysed the influence of high-dose intravenous immunoglobulin IVIG therapy on virus load on the level of anti-PL IgG and its potential capacity to improve the patients clinical status. Four juvenile patients with long-lasting polyarticular rheumatic diseases and persistent parvovirus B19 infection associated in three cases with the presence of antibodies against P2-glycoprotein I anti-P2GPI IgG were treated with two cycles of IVIG on five successive days 0.4g kg per day . Clinical parameters including scores of disease activity virus load and anti-PL IgG .