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báo cáo hóa học:" Analysis of ovarian tumor pathology by Fourier Transform Infrared Spectroscopy"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Analysis of ovarian tumor pathology by Fourier Transform Infrared Spectroscopy | Mehrotra et al. Journal of Ovarian Research 2010 3 27 http www.ovarianresearch.eom content 3 1 27 JOURNAL OF OVARIAN RESEARCH RESEARCH Open Access Analysis of ovarian tumor pathology by Fourier Transform Infrared Spectroscopy 1 -I- 1 1 2 2 Ranjana Mehrotra Gunjan Tyagi Deepak KJangir Ramesh Dawar Noopur Gupta Abstract Background Ovarian cancer is the second most common cancer among women and the leading cause of death among gynecologic malignancies. In recent years infrared IR spectroscopy has gained attention as a simple and inexpensive method for the biomedical study of several diseases. In the present study infrared spectra of normal and malignant ovarian tissues were recorded in the 650 cm-1 to 4000 cm-1 region. Methods Post surgical tissue samples were taken from the normal and tumor sections of the tissue. Fourier Transform Infrared FTIR data on twelve cases of ovarian cancer with different grades of malignancy from patients of different age groups were analyzed. Results Significant spectral differences between the normal and the ovarian cancerous tissues were observed. In particular changes in frequency and intensity in the spectral region of protein nucleic acid and lipid vibrational modes were observed. It was evident that the sample-to-sample or patient-to-patient variations were small and the spectral differences between normal and diseased tissues were reproducible. Conclusion The measured spectroscopic features which are the spectroscopic fingerprints of the tissues provided the important differentiating information about the malignant and normal tissues. The findings of this study demonstrate the possible use of infrared spectroscopy in differentiating normal and malignant ovarian tissues. Background Ovarian cancer is one of the leading causes of cancer-related deaths among women worldwide. In India the Indian Council of Medical Research reports the incidence rate of ovarian cancer as 4.2 per 100 000 women 1 . A woman has a lifetime risk of ovarian .