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Báo cáo y học: " Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals. | AIDS Research and Therapy BioMed Central Open Access Short report Partial protective effect of CCR5-Delta 32 heterozygosity in a cohort of heterosexual Italian HIV-1 exposed uninfected individuals Enrico M Trecarichi1 Mario Tumbarello 1 Katleen de Gaetano Donati1 Enrica Tamburrini1 Roberto Cauda1 Christina Brahe2 and Francesco D Tiziano2 Address Department of Infectious Diseases Catholic University Rome Italy and 2Department of Medical Genetics Catholic University Rome Italy Email Enrico M Trecarichi - e.trecarichi@gmail.com Mario Tumbarello - tumbarello@rm.unicatt.it Katleen de Gaetano Donati - kdegaetanodonati@yahoo.com Enrica Tamburrini - enricatamburrini@rm.unicatt.it Roberto Cauda - rcauda@rm.unicatt.it Christina Brahe - cbrahe@rm.unicatt.it Francesco D Tiziano - fdtiziano@rm.unicatt.it Corresponding author Published 25 September 2006 Received 15 June 2006 . A -n T J_ .IA I lorn-TA-. z Af - n Accepted 25 September 2006 AIDS Research and Therapy 2006 3 22 doi l0.ll86 l742-6405-3-22 This article is available from http www.aidsrestherapy.cOm content 3 1 22 2006 Trecarichi et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.Org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Despite multiple sexual exposure to HIV-1 virus some individuals remain HIV-1 seronegative exposed seronegative ESN . The mechanisms underlying this resistance remain still unclear although a multifactorial pathogenesis can be hypothesised. Although several genetic factors have been related to HIV-1 resistance the homozigosity for a mutation in CCR5 gene the 32 bp deletion i.e. CCR5-Delta32 allele is presently considered the most relevant one. In the present study we analysed the genotype at CCR5 locus