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Báo cáo y học: "Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genome-wide analysis of the diatom cell cycle unveils a novel type of cyclins involved in environmental signaling. | Huysman et al. Genome Biology 2010 11 R17 http genomebiology.eom 2010 11 2 R17 w Genome Biology RESEARCH Open Access Genome-wide analysis of the diatom cell eyele unveils a novel type of eyelins involved in environmental signaling Marie JJ Huysman 1 2 3 Cindy Martens2 3 Klaas Vandepoele2 3 Jeroen Gillard1 Edda Rayko4 Marc Heijde4 Chris Bowler4 Dirk Inzé2 3 Yves Van de Peer2 3 Lieven De Veylder2 3 and Wim Vyverman 1 Abstract Background Despite the enormous importance of diatoms in aquatic ecosystems and their broad industrial potential little is known about their life cycle control. Diatoms typically inhabit rapidly changing and unstable environments suggesting that cell cycle regulation in diatoms must have evolved to adequately integrate various environmental signals. The recent genome sequencing of Thalassiosirapseudonana and Phaeodactylum tricornutum allows us to explore the molecular conservation of cell cycle regulation in diatoms. Results By profile-based annotation of cell cycle genes counterparts of conserved as well as new regulators were identified in Tpseudonana and P tricornutum. In particular the cyclin gene family was found to be expanded extensively compared to that of other eukaryotes and a novel type of cyclins was discovered the diatom-specific cyclins. We established a synchronization method for P tricornutum that enabled assignment of the different annotated genes to specific cell cycle phase transitions. The diatom-specific cyclins are predominantly expressed at the G1-to-S transition and some respond to phosphate availability hinting at a role in connecting cell division to environmental stimuli. Conclusion The discovery of highly conserved and new cell cycle regulators suggests the evolution of unique control mechanisms for diatom cell division probably contributing to their ability to adapt and survive under highly fluctuating environmental conditions. Background Diatoms Bacillariophyceae are unicellular photosynthetic eukaryotes responsible