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Báo cáo khoa học: " Additive Estrogenic Activities of the Binary Mixtures of Four Estrogenic Chemicals in Recombinant Yeast Expressing Human Estrogen Receptor"

Tuyển tập các báo cáo nghiên cứu khoa học quốc tế về bệnh thú y đề tài: Additive Estrogenic Activities of the Binary Mixtures of Four Estrogenic Chemicals in Recombinant Yeast Expressing Human Estrogen Receptor | J. Vet. Sci. 2002 3 1 1-5 JOURNAL OF Veterinary Science Additive Estrogenic Activities of the Binary Mixtures of Four Estrogenic Chemicals in Recombinant Yeast Expressing Human Estrogen Receptor Kyung-Sun Kang Sung-Dae Cho and Yong-Soon Lee Department of Veterinary Public Health College of Veterinary Medicine School of Agricultural Biotechnology Seoul National University Seodun-Dong Kwonsun-Ku Suwon 441-744 Korea. ABSTRACT To evaluate the estrogenic activities of several chemicals such as 17 -estradiol E2 p -nonylphenol bisphenol A butylparaben and combinations of these chemicals we used recombinant yeasts containing the human estrogen receptor Saccharomyces cerevisiae ER LYS 8127 . We evaluated E2 was most active in the recombinant yeast assay followed by p-nonylphenol bisphenol A butylparaben. The combinations of some concentrations of 17-estradiol as a strong estrogen and bisphenol A or butylparaben as a weak estrogen showed additive estrogenic effects. Also the combinations of some concentrations of nonlyphenol and butylparaben and combination of butylparaben and bisphenol A showed additive effects in the estrogenic activity. Therefore the estrogenic activities of the combinations of two chemicals were additive not synergistic. Key words Recombinant yeast human estrogen receptor -galactosidase combination additive INTRODUCTION There has been increasing public concern that chemicals in the environment are affecting human health by disrupting normal endocrine function particularly through interaction directly with steroid hormone receptors. The exposure to these chemicals with steroid-like activity can disrupt normal endocrine function leading to alter reproductive capacity infertility endometriosis and breast and uterine cancer 1 2 3 4 5 6 . A wide variety of chemicals have steroid-like activity including natural products such as coumestrol and genistein pesticides and fungicides such as DDT and Corresponding author Yong Soon Lee D.V.M. Ph.D. Department of .